Carbonic anhydrase 12
Also known as: CA12
Function
Reversible hydration of carbon dioxide.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Secreted Growth Factors & Cytokines
Experimental structures · PDB · 40
- 1JCZ X-ray 1.55A
- 1JD0 X-ray 1.50A
- 4HT2 X-ray 1.45A
- 4KP5 X-ray 1.45A
- 4KP8 X-ray 1.80A
- 4Q0L X-ray 2.00A
- 4QJ0 X-ray 1.55A
- 4QJO X-ray 1.80A
- 4QJW X-ray 1.55A
- 4WW8 X-ray 1.42A
- 5LL5 X-ray 1.42A
- 5LL9 X-ray 1.45A
- … and 28 more
A predicted model is available from AlphaFold.
Gene Ontology · 8
Disease associations
- isolated hyperchlorhidrosis MONDO:0007747
Drugs targeting this protein · 5
- ACETAZOLAMIDE SODIUM inhibitor
- DICHLORPHENAMIDE inhibitor
- ETHOXZOLAMIDE inhibitor
- ACETAZOLAMIDE inhibitor
- SULTHIAME inhibitor
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- Carbonic anhydrase 12 0.98
- Carbonic anhydrase 12 0.94
- Carbonic anhydrase 4 0.88
- Carbonic anhydrase 4 0.88
- Carbonic anhydrase 4 0.86
- Carbonic anhydrase 4 0.86
- Carbonic anhydrase 4 0.86
- Carbonic anhydrase 15 0.84
- Carbonic anhydrase 6 0.84
- Putative carbonic anhydrase 5 0.82
- Carbonic anhydrase 14 0.82
- Carbonic anhydrase 9 0.80
Co-cited proteins · studied together in the literature
- Carbonic anhydrase 1 5 shared papers
- Carbonic anhydrase 2 6 shared papers
- Carbonic anhydrase 5B, mitochondrial 4 shared papers
- Carbonic anhydrase 6 4 shared papers
- Carbonic anhydrase 9 4 shared papers
- Carbonic anhydrase 14 5 shared papers
- Carbonic anhydrase 4 5 shared papers
- Carbonic anhydrase 3 3 shared papers
- Carbonic anhydrase 7 4 shared papers
- Carbonic anhydrase 5A, mitochondrial 4 shared papers
- Carbonic anhydrase 13 3 shared papers
- Carbonic anhydrase 13 1 shared papers
Literature · 14 cited papers
- Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. Hum. Mol. Genet. · 2016
- Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of carbonic cnhydrase 12. Hum. Genet. · 2011
- Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII. Am. J. Hum. Genet. · 2010
- Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
- A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
- Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
- Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
- Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II. J. Am. Chem. Soc. · 2007
- Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc. Natl. Acad. Sci. U.S.A. · 2001
- … and 2 more in the literature graph
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