Carbonic anhydrase 5B, mitochondrial

Function

Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3.

Classification

Family (Pfam)

PF00194 Carb_anhydrase

InterPro

CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS

Functional cluster

Eukaryotic Transcription Factors & related

Gene Ontology · 5

• GO:0005737 cytoplasm
• GO:0005759 mitochondrial matrix
• GO:0005739 mitochondrion
• GO:0004089 carbonate dehydratase activity
• GO:0008270 zinc ion binding

Drugs targeting this protein · 2

• ETHOXZOLAMIDE inhibitor
• SULTHIAME inhibitor

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Carbonic anhydrase 5B, mitochondrial 0.98
• Carbonic anhydrase 5B, mitochondrial 0.98
• Carbonic anhydrase 5A, mitochondrial 0.88
• Carbonic anhydrase 5A, mitochondrial 0.88
• Carbonic anhydrase 5A, mitochondrial 0.85
• Carbonic anhydrase 7 0.83
• Carbonic anhydrase 7 0.83
• Carbonic anhydrase 3 0.83
• Carbonic anhydrase 3 0.83
• Carbonic anhydrase 3 0.83
• Carbonic anhydrase 3 0.81
• Carbonic anhydrase 13 0.81

Co-cited proteins · studied together in the literature

• Carbonic anhydrase 6 4 shared papers
• Carbonic anhydrase 9 4 shared papers
• Carbonic anhydrase 12 4 shared papers
• Carbonic anhydrase 7 4 shared papers
• Carbonic anhydrase 14 4 shared papers
• Carbonic anhydrase 4 4 shared papers
• Carbonic anhydrase 13 3 shared papers
• Carbonic anhydrase 5A, mitochondrial 3 shared papers
• Carbonic anhydrase 3 2 shared papers
• Carbonic anhydrase 2 4 shared papers
• Carbonic anhydrase 15 1 shared papers
• Carbonic anhydrase 1 3 shared papers

Literature · 7 cited papers

• Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
• Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
• Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X. J. Biol. Chem. · 1999