Carbonic anhydrase 14

Function

Reversible hydration of carbon dioxide.

Classification

Family (Pfam)

PF00194 Carb_anhydrase

InterPro

CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 2

• 4LU3 X-ray 2.00A
• 5CJF X-ray 1.83A

A predicted model is available from AlphaFold.

Gene Ontology · 4

• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0004089 carbonate dehydratase activity
• GO:0008270 zinc ion binding

Drugs targeting this protein · 2

• ETHOXZOLAMIDE inhibitor
• SULTHIAME inhibitor

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Carbonic anhydrase 14 0.98
• Carbonic anhydrase 9 0.78
• Carbonic anhydrase 12 0.76
• Carbonic anhydrase 12 0.75
• Carbonic anhydrase 6 0.75
• Carbonic anhydrase 5A, mitochondrial 0.71
• Carbonic anhydrase 6 0.71
• Carbonic anhydrase 9 0.70
• Carbonic anhydrase 4 0.70
• Carbonic anhydrase 6 0.70
• Carbonic anhydrase 15 0.69
• Carbonic anhydrase 4 0.69

Co-cited proteins · studied together in the literature

• Carbonic anhydrase 4 8 shared papers
• Carbonic anhydrase 7 7 shared papers
• Carbonic anhydrase 5A, mitochondrial 7 shared papers
• Carbonic anhydrase 1 7 shared papers
• Carbonic anhydrase 2 8 shared papers
• Carbonic anhydrase 12 5 shared papers
• Carbonic anhydrase 5B, mitochondrial 4 shared papers
• Carbonic anhydrase 6 4 shared papers
• Carbonic anhydrase 9 4 shared papers
• Carbonic anhydrase 3 3 shared papers
• Carbonic anhydrase 13 3 shared papers
• Carbonic anhydrase 13 1 shared papers

Literature · 16 cited papers

• The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
• Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
• Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
• Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
• Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. · 2007
• Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry · 2006
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. · 2006
• … and 4 more in the literature graph