Carbonic anhydrase 9

Function

Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions).

Classification

Family (Pfam)

PF00194 Carb_anhydrase

InterPro

CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 30

• 2HKF X-ray 2.01A
• 3IAI X-ray 2.20A
• 5DVX X-ray 1.60A
• 5FL4 X-ray 1.82A
• 5FL5 X-ray 2.05A
• 5FL6 X-ray 1.95A
• 6FE0 X-ray 1.91A
• 6FE1 X-ray 1.95A
• 6FE2 X-ray 1.87A
• 6G98 X-ray 2.47A
• 6G9U X-ray 1.75A
• 6QN2 X-ray 1.95A
• … and 18 more

A predicted model is available from AlphaFold.

Gene Ontology · 11

• GO:0016323 basolateral plasma membrane
• GO:0016020 membrane
• GO:0031528 microvillus membrane
• GO:0005730 nucleolus
• GO:0005886 plasma membrane
• GO:0004089 carbonate dehydratase activity
• GO:0140677 molecular function activator activity
• GO:0008270 zinc ion binding
• GO:0001666 response to hypoxia
• GO:0033574 response to testosterone
• GO:0009410 response to xenobiotic stimulus

Drugs targeting this protein · 2

• ETHOXZOLAMIDE inhibitor
• SULTHIAME inhibitor

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Carbonic anhydrase 9 0.94
• Carbonic anhydrase 15 0.84
• Carbonic anhydrase 4 0.81
• Carbonic anhydrase-related protein 11 0.79
• Carbonic anhydrase-related protein 11 0.79
• Carbonic anhydrase-related protein 11 0.78
• Carbonic anhydrase-related protein 11 0.78
• Carbonic anhydrase-related protein 11 0.78
• Carbonic anhydrase-related protein 11 0.77
• Carbonic anhydrase 4 0.77
• Carbonic anhydrase 4 0.76
• Carbonic anhydrase 14 0.76

Co-cited proteins · studied together in the literature

• Carbonic anhydrase 5B, mitochondrial 4 shared papers
• Carbonic anhydrase 6 4 shared papers
• Carbonic anhydrase 12 4 shared papers
• Carbonic anhydrase 7 4 shared papers
• Carbonic anhydrase 14 4 shared papers
• Carbonic anhydrase 4 4 shared papers
• Carbonic anhydrase 13 3 shared papers
• Carbonic anhydrase 5A, mitochondrial 3 shared papers
• Carbonic anhydrase 3 2 shared papers
• Carbonic anhydrase 2 4 shared papers
• Carbonic anhydrase 15 1 shared papers
• Carbonic anhydrase 1 3 shared papers

Literature · 16 cited papers

• Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc. Natl. Acad. Sci. U.S.A. · 2009
• Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
• Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J. Biol. Chem. · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations. Proteins · 2008
• Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
• Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
• The role of carbonic anhydrase IX overexpression in kidney cancer. Eur. J. Cancer · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• … and 4 more in the literature graph