Carbonic anhydrase 3

Function

Reversible hydration of carbon dioxide.

Classification

Family (Pfam)

PF00194 Carb_anhydrase

InterPro

CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS

Functional cluster

Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 5

• 1Z93 X-ray 2.10A
• 1Z97 X-ray 2.10A
• 2HFW X-ray 2.50A
• 3UYN X-ray 2.60A
• 3UYQ X-ray 1.70A

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005634 nucleus
• GO:0030017 sarcomere
• GO:0004089 carbonate dehydratase activity
• GO:0016791 phosphatase activity
• GO:0008270 zinc ion binding
• GO:0071456 cellular response to hypoxia
• GO:0032869 cellular response to insulin stimulus
• GO:0044320 cellular response to leptin stimulus
• GO:0097421 liver regeneration
• GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
• GO:1903427 negative regulation of reactive oxygen species biosynthetic process
• GO:0008284 positive regulation of cell population proliferation
• GO:0045471 response to ethanol
• GO:0033993 response to lipid
• GO:0006979 response to oxidative stress
• GO:0003009 skeletal muscle contraction

Drugs targeting this protein · 2

• ETHOXZOLAMIDE inhibitor
• SULTHIAME inhibitor

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Carbonic anhydrase 3 0.99
• Carbonic anhydrase 3 0.99
• Carbonic anhydrase 3 0.98
• Carbonic anhydrase 3 0.98
• Carbonic anhydrase 3 0.98
• Carbonic anhydrase 13 0.95
• Carbonic anhydrase 1 0.94
• Carbonic anhydrase 2 0.94
• Carbonic anhydrase 13 0.94
• Carbonic anhydrase 2 0.93
• Carbonic anhydrase 2 0.92
• Carbonic anhydrase 7 0.92

Co-cited proteins · studied together in the literature

• Carbonic anhydrase 12 3 shared papers
• Carbonic anhydrase 5A, mitochondrial 3 shared papers
• Carbonic anhydrase 14 3 shared papers
• Carbonic anhydrase 4 3 shared papers
• Carbonic anhydrase 13 1 shared papers
• Carbonic anhydrase 1 3 shared papers
• Carbonic anhydrase 13 2 shared papers
• Carbonic anhydrase 5B, mitochondrial 2 shared papers
• Carbonic anhydrase 6 2 shared papers
• Carbonic anhydrase 9 2 shared papers
• Carbonic anhydrase 15 1 shared papers
• Carbonic anhydrase 2 3 shared papers

Literature · 12 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
• Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
• Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins · 2007
• Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. Biochemistry · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Gene · 1998
• Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes. Proc. Natl. Acad. Sci. U.S.A. · 1986
• Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase. Gene · 1986
• Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues. Genes Dev. · 1987