Carbonic anhydrase 6

Function

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Classification

Family (Pfam)

PF00194 Carb_anhydrase

InterPro

CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS

Functional cluster

Secreted Hydrolases & Toxins

Experimental structures · PDB · 1

• 3FE4 X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0004089 carbonate dehydratase activity
• GO:0008270 zinc ion binding
• GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste

Drugs targeting this protein · 2

• ETHOXZOLAMIDE inhibitor
• SULTHIAME inhibitor

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Carbonic anhydrase 6 0.96
• Carbonic anhydrase 6 0.96
• Carbonic anhydrase 6 0.95
• Carbonic anhydrase 6 0.88
• Alpha carbonic anhydrase 5 0.81
• Carbonic anhydrase 12 0.80
• Alpha carbonic anhydrase 2 0.79
• Carbonic anhydrase-related protein 10 0.79
• Carbonic anhydrase-related protein 10 0.79
• Carbonic anhydrase-related protein 10 0.79
• Carbonic anhydrase-related protein 10 0.79
• Alpha carbonic anhydrase 1, chloroplastic 0.79

Co-cited proteins · studied together in the literature

• Carbonic anhydrase 5B, mitochondrial 4 shared papers
• Carbonic anhydrase 9 4 shared papers
• Carbonic anhydrase 12 4 shared papers
• Carbonic anhydrase 7 4 shared papers
• Carbonic anhydrase 14 4 shared papers
• Carbonic anhydrase 4 4 shared papers
• Carbonic anhydrase 13 3 shared papers
• Carbonic anhydrase 5A, mitochondrial 3 shared papers
• Carbonic anhydrase 3 2 shared papers
• Carbonic anhydrase 2 4 shared papers
• Carbonic anhydrase 15 1 shared papers
• Carbonic anhydrase 1 3 shared papers

Literature · 7 cited papers

• Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
• Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
• Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Crystal structure of human erythrocyte carbonic anhydrase C. VI. The three-dimensional structure at high resolution in relation to other mammalian carbonic anhydrases. Cold Spring Harb. Symp. Quant. Biol. · 1972
• Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. Biochemistry · 1991