Carbonic anhydrase 7
Also known as: CA7
Function
Reversible hydration of carbon dioxide.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- Alpha_CA_VII, CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Cytochrome P450 & Heme Enzymes
Experimental structures · PDB · 11
- 3MDZ X-ray 2.32A
- 3ML5 X-ray 2.05A
- 6G4T X-ray 1.91A
- 6H36 X-ray 1.85A
- 6H37 X-ray 1.90A
- 6H38 X-ray 1.70A
- 6SDT X-ray 1.94A
- 6ZR9 X-ray 2.05A
- 7NC4 X-ray 1.60A
- 7P1A X-ray 1.58A
- 8Q3U X-ray 1.10A
A predicted model is available from AlphaFold.
Gene Ontology · 5
Drugs targeting this protein · 3
- ETHOXZOLAMIDE inhibitor
- METHAZOLAMIDE inhibitor
- SULTHIAME inhibitor
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- Carbonic anhydrase 7 0.99
- Carbonic anhydrase 13 0.94
- Carbonic anhydrase 3 0.92
- Carbonic anhydrase 13 0.92
- Carbonic anhydrase 2 0.92
- Carbonic anhydrase 2 0.91
- Carbonic anhydrase 3 0.91
- Carbonic anhydrase 3 0.91
- Carbonic anhydrase 3 0.91
- Carbonic anhydrase 3 0.91
- Carbonic anhydrase 3 0.90
- Carbonic anhydrase 2 0.89
Co-cited proteins · studied together in the literature
- Carbonic anhydrase 14 7 shared papers
- Carbonic anhydrase 4 7 shared papers
- Carbonic anhydrase 5A, mitochondrial 6 shared papers
- Carbonic anhydrase 1 6 shared papers
- Carbonic anhydrase 2 7 shared papers
- Carbonic anhydrase 5B, mitochondrial 4 shared papers
- Carbonic anhydrase 6 4 shared papers
- Carbonic anhydrase 9 4 shared papers
- Carbonic anhydrase 12 4 shared papers
- Carbonic anhydrase 13 3 shared papers
- Carbonic anhydrase 3 2 shared papers
- Carbonic anhydrase 15 1 shared papers
Literature · 10 cited papers
- Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
- A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
- Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew. Chem. Int. Ed. Engl. · 2007
- Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
- Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. · 2007
- Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry · 2006
- Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics · 1999
- Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. Genomics · 1991
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