Carbonic anhydrase 1

UniProt P00915 Organism Homo sapiens Gene CA1 EC 4.2.1.1, 4.2.1.69

Also known as: CA1

Function

Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.

Classification

Family (Pfam): PF00194 Carb_anhydrase
InterPro: CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
Functional cluster: Adenylate Kinases & Peroxiredoxins

Experimental structures · PDB · 55

1AZM X-ray 2.00A
1BZM X-ray 2.00A
1CRM X-ray 2.00A
1CZM X-ray 2.00A
1HCB X-ray 1.60A
1HUG X-ray 2.00A
1HUH X-ray 2.20A
1J9W X-ray 2.60A
1JV0 X-ray 2.00A
2CAB X-ray 2.00A
2FOY X-ray 1.55A
2FW4 X-ray 2.00A
… and 43 more

A predicted model is available from AlphaFold.

Gene Ontology · 9

Drugs targeting this protein · 8

ACETAZOLAMIDE SODIUM inhibitor
METHOCARBAMOL inhibitor
POLMACOXIB inhibitor
DICHLORPHENAMIDE inhibitor
ETHOXZOLAMIDE inhibitor
METHAZOLAMIDE inhibitor
ACETAZOLAMIDE inhibitor
SULTHIAME inhibitor

Neighborhood · nearest proteins

Nearest neighbours of Carbonic anhydrase 1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Carbonic anhydrase 2 11 shared papers
Carbonic anhydrase 5A, mitochondrial 7 shared papers
Carbonic anhydrase 12 5 shared papers
Carbonic anhydrase 14 7 shared papers
Carbonic anhydrase 4 7 shared papers
Carbonic anhydrase 7 6 shared papers
Carbonic anhydrase 3 3 shared papers
Carbonic anhydrase 13 3 shared papers
Carbonic anhydrase 5B, mitochondrial 3 shared papers
Carbonic anhydrase 6 3 shared papers
Carbonic anhydrase 9 3 shared papers
Carbonic anhydrase 13 1 shared papers

Literature · 29 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II. J. Am. Chem. Soc. · 2007
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. · 2007
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I. Bioorg. Med. Chem. Lett. · 2006
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry · 2006
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. · 2006
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity. J. Am. Chem. Soc. · 2006
… and 17 more in the literature graph

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