Carbonic anhydrase 13
Also known as: CA13
Function
Catalyzes the reversible conversion of carbon dioxide to hydrogencarbonate/bicarbonate and thus is essential in the regulation of pH and metabolic processes.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Cytochrome P450 & Heme Enzymes
Experimental structures · PDB · 18
- 3CZV X-ray 2.00A
- 3D0N X-ray 1.55A
- 3DA2 X-ray 2.05A
- 4HU1 X-ray 1.95A
- 4KNM X-ray 1.90A
- 4KNN X-ray 1.40A
- 4QIZ X-ray 1.55A
- 4QJP X-ray 1.62A
- 4QJX X-ray 1.95A
- 4QSJ X-ray 1.70A
- 5E2N X-ray 1.53A
- 5LLA X-ray 1.50A
- … and 6 more
A predicted model is available from AlphaFold.
Gene Ontology · 4
Drugs targeting this protein · 2
- ETHOXZOLAMIDE inhibitor
- SULTHIAME inhibitor
Related proteins · sequence + function similarity
- Carbonic anhydrase 13 0.99
- Carbonic anhydrase 2 0.94
- Carbonic anhydrase 3 0.94
- Carbonic anhydrase 3 0.92
- Carbonic anhydrase 2 0.92
- Carbonic anhydrase 3 0.92
- Carbonic anhydrase 1 0.92
- Carbonic anhydrase 3 0.92
- Carbonic anhydrase 3 0.92
- Carbonic anhydrase 2 0.92
- Carbonic anhydrase 7 0.92
- Carbonic anhydrase 7 0.92
Co-cited proteins · studied together in the literature
- Carbonic anhydrase 13 1 shared papers
- Carbonic anhydrase 3 1 shared papers
- Carbonic anhydrase 12 1 shared papers
- Carbonic anhydrase 5A, mitochondrial 1 shared papers
- Carbonic anhydrase 14 1 shared papers
- Carbonic anhydrase 4 1 shared papers
- Carbonic anhydrase 1 1 shared papers
- Carbonic anhydrase 2 1 shared papers
Literature · 5 cited papers
- Affinity and Selectivity of Protein-Ligand Recognition: A Minor Chemical Modification Changes Carbonic Anhydrase Binding Profile. J. Med. Chem. · 2025
- Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J. Biol. Chem. · 2004
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