Carbonic anhydrase 5A, mitochondrial
Also known as: CA5, CA5A
Function
Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3. Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Eukaryotic Transcription Factors & related
Gene Ontology · 5
Disease associations
Drugs targeting this protein · 2
- ETHOXZOLAMIDE inhibitor
- SULTHIAME inhibitor
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- Carbonic anhydrase 5A, mitochondrial 0.94
- Carbonic anhydrase 5A, mitochondrial 0.94
- Carbonic anhydrase 5B, mitochondrial 0.89
- Carbonic anhydrase 5B, mitochondrial 0.89
- Carbonic anhydrase 5B, mitochondrial 0.88
- Carbonic anhydrase 7 0.76
- Carbonic anhydrase 7 0.75
- Carbonic anhydrase 14 0.73
- Carbonic anhydrase 13 0.72
- Carbonic anhydrase 14 0.71
- Carbonic anhydrase 3 0.71
- Carbonic anhydrase 3 0.70
Co-cited proteins · studied together in the literature
- Carbonic anhydrase 14 7 shared papers
- Carbonic anhydrase 4 7 shared papers
- Carbonic anhydrase 7 6 shared papers
- Carbonic anhydrase 1 7 shared papers
- Carbonic anhydrase 2 7 shared papers
- Carbonic anhydrase 3 3 shared papers
- Carbonic anhydrase 12 4 shared papers
- Carbonic anhydrase 13 3 shared papers
- Carbonic anhydrase 5B, mitochondrial 3 shared papers
- Carbonic anhydrase 6 3 shared papers
- Carbonic anhydrase 9 3 shared papers
- Carbonic anhydrase 13 1 shared papers
Literature · 12 cited papers
- Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood. Am. J. Hum. Genet. · 2014
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
- A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
- Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins · 2009
- Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg. Med. Chem. Lett. · 2007
- Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. · 2007
- Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry · 2006
- Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16. Proc. Natl. Acad. Sci. U.S.A. · 1993
- Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. Genomics · 1995
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