Carbonic anhydrase 2

UniProt P00918 Organism Homo sapiens Gene CA2 EC 4.2.1.1, 4.2.1.69

Also known as: CA2

Function

Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.

Classification

Family (Pfam): PF00194 Carb_anhydrase
InterPro: CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
Functional cluster: Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 1182

12CA X-ray 2.40A
1A42 X-ray 2.25A
1AM6 X-ray 2.00A
1AVN X-ray 2.00A
1BCD X-ray 1.90A
1BIC X-ray 1.90A
1BN1 X-ray 2.10A
1BN3 X-ray 2.20A
1BN4 X-ray 2.10A
1BNM X-ray 2.60A
1BNN X-ray 2.30A
1BNQ X-ray 2.40A
… and 1170 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

Disease associations

autosomal recessive osteopetrosis 3 MONDO:0009818

Drugs targeting this protein · 10

ACETAZOLAMIDE SODIUM inhibitor
DORZOLAMIDE HYDROCHLORIDE inhibitor
POLMACOXIB inhibitor
DICHLORPHENAMIDE inhibitor
ETHOXZOLAMIDE inhibitor
METHAZOLAMIDE inhibitor
ACETAZOLAMIDE inhibitor
BRINZOLAMIDE inhibitor
TOPIRAMATE inhibitor
SULTHIAME inhibitor

Neighborhood · nearest proteins

Nearest neighbours of Carbonic anhydrase 2: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Carbonic anhydrase 1 11 shared papers
Carbonic anhydrase 4 2 shared papers
Carbonic anhydrase 2 1 shared papers
Sodium bicarbonate cotransporter 3 1 shared papers
Solute carrier family 26 member 6 1 shared papers
Carbonic anhydrase 12 6 shared papers
Carbonic anhydrase 14 8 shared papers
Carbonic anhydrase 4 8 shared papers
Carbonic anhydrase 7 7 shared papers
Carbonic anhydrase 5A, mitochondrial 7 shared papers
Electrogenic sodium bicarbonate cotransporter 1 2 shared papers
Electrogenic sodium bicarbonate cotransporter 1 2 shared papers

Literature · 118 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J. Med. Chem. · 2009
Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR. J. Phys. Chem. B · 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. J. Med. Chem. · 2009
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry · 2009
Structural study of X-ray induced activation of carbonic anhydrase. Proc. Natl. Acad. Sci. U.S.A. · 2009
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. · 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg. Med. Chem. Lett. · 2009
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry · 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. J. Med. Chem. · 2009
Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry · 2008
… and 106 more in the literature graph

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