Electrogenic sodium bicarbonate cotransporter 1

UniProt Q9Y6R1 Organism Homo sapiens Gene NBC, NBC1, NBCE1, SLC4A4

Also known as: NBC, NBC1, NBCE1, SLC4A4

Function

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.

Classification

Family (Pfam): PF07565 Band_3_cyto, PF00955 HCO3_cotransp
InterPro: Band3_cytoplasmic_dom, HCO3_transpt-like_TM_dom, HCO3_transpt_euk, Na/HCO3_transpt, PTrfase/Anion_transptr
Functional cluster: Nucleotide & Amino-Acid Biosynthesis Enzymes

Experimental structures · PDB · 1

6CAA EM 3.90A

A predicted model is available from AlphaFold.

Gene Ontology · 19

Disease associations

autosomal recessive proximal renal tubular acidosis MONDO:0011422

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Electrogenic sodium bicarbonate cotransporter 1 2 shared papers
Electrogenic sodium bicarbonate cotransporter 1 2 shared papers
Electrogenic sodium bicarbonate cotransporter 1 5 shared papers
Carbonic anhydrase 4 1 shared papers
Carbonic anhydrase 4 1 shared papers
Electrogenic sodium bicarbonate cotransporter 1 1 shared papers
Carbonic anhydrase 4 1 shared papers
Carbonic anhydrase 2 2 shared papers
S-adenosylhomocysteine hydrolase-like protein 1 1 shared papers
S-adenosylhomocysteine hydrolase-like protein 1 1 shared papers

Literature · 31 cited papers

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1. Nat. Commun. · 2018
Interplay between disulfide bonding and N-glycosylation defines SLC4 Na+-coupled transporter extracellular topography. J. Biol. Chem. · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis. Am. J. Physiol. · 2013
Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits. Am. J. Physiol. · 2013
Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis. Pflugers Arch. · 2008
IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3-cotransporter 1 (pNBC1). Proc. Natl. Acad. Sci. U.S.A. · 2006
Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1). Mol. Vis. · 2006
Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. J. Am. Soc. Nephrol. · 2005
Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport. J. Physiol. (Lond.) · 2005
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis. Am. J. Physiol. · 2005
… and 19 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.