Carbonic anhydrase 4
Also known as: Ca4, Car4
Function
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA4/CA15, CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Secreted Growth Factors & Cytokines
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 13
- GO:0031526 brush border membrane
- GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
- GO:0009897 external side of plasma membrane
- GO:0070062 extracellular exosome
- GO:0048471 perinuclear region of cytoplasm
- GO:0005886 plasma membrane
- GO:0005791 rough endoplasmic reticulum
- GO:0030667 secretory granule membrane
- GO:0005802 trans-Golgi network
- GO:0030658 transport vesicle membrane
- GO:0004089 carbonate dehydratase activity
- GO:0008270 zinc ion binding
- GO:0015701 bicarbonate transport
Related proteins · sequence + function similarity
- Carbonic anhydrase 4 0.96
- Carbonic anhydrase 4 0.93
- Carbonic anhydrase 4 0.93
- Carbonic anhydrase 4 0.89
- Carbonic anhydrase 12 0.88
- Carbonic anhydrase 12 0.87
- Carbonic anhydrase 12 0.86
- Putative carbonic anhydrase 5 0.83
- Carbonic anhydrase 15 0.83
- Carbonic anhydrase 6 0.77
- Carbonic anhydrase 6 0.74
- Carbonic anhydrase-like 3 0.73
Co-cited proteins · studied together in the literature
- Carbonic anhydrase 2 2 shared papers
- Carbonic anhydrase 4 1 shared papers
- Electrogenic sodium bicarbonate cotransporter 1 1 shared papers
- Electrogenic sodium bicarbonate cotransporter 1 1 shared papers
Literature · 5 cited papers
- A tissue-specific atlas of mouse protein phosphorylation and expression. Cell · 2010
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry · 2003
- Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci. · 1998
- Molecular cloning of the mouse gene coding for carbonic anhydrase IV. Biochem. Genet. · 1996
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