Carbonic anhydrase 4
Also known as: Ca4
Function
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA4/CA15, CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class, Carbonic_anhydrase_a-class_CS
- Functional cluster
- Immunoglobulin & Immune-Response Proteins
Gene Ontology · 20
- GO:0016324 apical plasma membrane
- GO:0031526 brush border membrane
- GO:0009986 cell surface
- GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
- GO:0009897 external side of plasma membrane
- GO:0070062 extracellular exosome
- GO:0005794 Golgi apparatus
- GO:0048471 perinuclear region of cytoplasm
- GO:0005886 plasma membrane
- GO:0005791 rough endoplasmic reticulum
- GO:0042383 sarcolemma
- GO:0016529 sarcoplasmic reticulum
- GO:0030667 secretory granule membrane
- GO:0005802 trans-Golgi network
- GO:0030658 transport vesicle membrane
- GO:0004089 carbonate dehydratase activity
- GO:0008270 zinc ion binding
- GO:0015701 bicarbonate transport
- GO:0048545 response to steroid hormone
- GO:0009410 response to xenobiotic stimulus
Related proteins · sequence + function similarity
- Carbonic anhydrase 4 0.96
- Carbonic anhydrase 4 0.93
- Carbonic anhydrase 4 0.91
- Carbonic anhydrase 12 0.88
- Carbonic anhydrase 12 0.88
- Carbonic anhydrase 4 0.87
- Carbonic anhydrase 12 0.82
- Putative carbonic anhydrase 5 0.81
- Carbonic anhydrase 15 0.81
- Carbonic anhydrase 6 0.75
- Carbonic anhydrase 6 0.74
- Alpha carbonic anhydrase 2 0.72
Literature · 4 cited papers
- Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity. J. Proteome Res. · 2013
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Pulmonary carbonic anhydrase IV: developmental regulation and cell-specific expression in the capillary endothelium. Am. J. Physiol. · 1993
- Membrane-associated carbonic anhydrase from rat lung. Purification, characterization, tissue distribution, and comparison with carbonic anhydrase IVs of other mammals. J. Biol. Chem. · 1992
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