Carbonic anhydrase 4
Also known as: CA4
Function
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Classification
- Family (Pfam)
- PF00194 Carb_anhydrase
- InterPro
- CA4/CA15, CA_dom, CA_dom_sf, Carbonic_anhydrase_a-class
- Functional cluster
- Secreted Growth Factors & Cytokines
Gene Ontology · 4
Related proteins · sequence + function similarity
- Carbonic anhydrase 4 0.97
- Carbonic anhydrase 4 0.97
- Carbonic anhydrase 4 0.93
- Carbonic anhydrase 15 0.92
- Carbonic anhydrase 4 0.91
- Carbonic anhydrase 12 0.86
- Carbonic anhydrase 12 0.85
- Carbonic anhydrase 12 0.84
- Carbonic anhydrase 9 0.81
- Carbonic anhydrase-related protein 11 0.81
- Carbonic anhydrase-related protein 11 0.80
- Carbonic anhydrase-related protein 11 0.80
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