26S proteasome non-ATPase regulatory subunit 2

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01851 PC_rep, PF18051 RPN1_C, PF17781 RPN1_RPN2_N

InterPro

26S_Psome_Rpn1, ARM-like, ARM-type_fold, Proteasome/cyclosome_rpt, RPN1_C, RPN1_N

Functional cluster

S-Adenosylmethionine Synthases & related

Experimental structures · PDB · 85

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• 5VFR EM 4.90A
• … and 73 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0008540 proteasome regulatory particle, base subcomplex
• GO:0034515 proteasome storage granule
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0030234 enzyme regulator activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 2 1.00
• 26S proteasome non-ATPase regulatory subunit 2 1.00
• 26S proteasome non-ATPase regulatory subunit 2 1.00
• 26S proteasome non-ATPase regulatory subunit 2 1.00
• 26S proteasome non-ATPase regulatory subunit 2 homolog B 0.96
• 26S proteasome non-ATPase regulatory subunit 2 homolog A 0.96
• 26S proteasome regulatory subunit rpn-1 0.90
• 26S proteasome regulatory subunit rpn1 0.90
• 26S proteasome non-ATPase regulatory subunit 2 0.89
• 26S proteasome regulatory subunit RPN1 0.82
• 26S proteasome regulatory subunit RPN1 0.82
• 26S proteasome non-ATPase regulatory subunit 1 0.76

Co-cited proteins · studied together in the literature

• 26S proteasome non-ATPase regulatory subunit 2 1 shared papers
• Ubiquitin-like domain-containing CTD phosphatase 1 1 shared papers
• 26S proteasome regulatory subunit 7 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 11 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 3 3 shared papers

Literature · 24 cited papers

• Phosphatase UBLCP1 controls proteasome assembly. Open Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• … and 12 more in the literature graph