26S proteasome regulatory subunit 7

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Classification

Family (Pfam)

PF00004 AAA, PF17862 AAA_lid_3, PF21236 OB_PRS7

InterPro

26S_Proteasome_ATPase, AAA+_ATPase, AAA_lid_3, ATPase_AAA_core, ATPase_AAA_CS, NA-bd_OB-fold, OB_PRS7, P-loop_NTPase

Functional cluster

ABC Transporter ATPases & DnaJ Chaperones

Experimental structures · PDB · 87

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4G EM 4.02A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 75 more

A predicted model is available from AlphaFold.

Gene Ontology · 25

• GO:0005737 cytoplasm
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0000932 P-body
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0008540 proteasome regulatory particle, base subcomplex
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0036402 proteasome-activating activity
• GO:0071357 cellular response to type I interferon
• GO:0001649 osteoblast differentiation
• GO:1901800 positive regulation of proteasomal protein catabolic process
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress
• GO:0006511 ubiquitin-dependent protein catabolic process

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome regulatory subunit 7 1.00
• 26S proteasome regulatory subunit 7 1.00
• 26S proteasome regulatory subunit 7 1.00
• 26S proteasome regulatory subunit 7 1.00
• 26S proteasome regulatory subunit 7 1.00
• 26S proteasome regulatory subunit 7 0.95
• 26S proteasome regulatory subunit 7 homolog 0.94
• 26S proteasome regulatory subunit 7 0.92
• 26S proteasome regulatory subunit 7 homolog A 0.92
• 26S proteasome regulatory subunit 7 0.90
• 26S proteasome regulatory subunit 10B 0.90
• 26S proteasome regulatory subunit 7B 0.90

Co-cited proteins · studied together in the literature

• Ubiquitin-like domain-containing CTD phosphatase 1 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 4 shared papers
• 26S proteasome regulatory subunit 8 7 shared papers
• E3 ubiquitin-protein ligase RNF181 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 4 4 shared papers
• Structural maintenance of chromosomes protein 1A 2 shared papers
• Proteasomal ubiquitin receptor ADRM1 1 shared papers
• 26S proteasome regulatory subunit 6B 5 shared papers
• 26S proteasome regulatory subunit 10B 4 shared papers
• Proteasomal ATPase-associated factor 1 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 4 shared papers
• Kinetochore protein NDC80 homolog 2 shared papers

Literature · 24 cited papers

• Phosphatase UBLCP1 controls proteasome assembly. Open Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. EMBO J. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol. Cell. Biol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 12 more in the literature graph