26S proteasome non-ATPase regulatory subunit 7

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01398 JAB, PF13012 MitMem_reg

InterPro

EIF3F/CSN6-like_C, JAMM/MPN+_dom, MPN, MPN_RPN7_8

Functional cluster

Zinc-Finger Nucleic-Acid-Binding & Methyltransferases

Experimental structures · PDB · 80

• 2O95 X-ray 1.95A
• 2O96 X-ray 3.00A
• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• … and 68 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0042803 protein homodimerization activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 7 1.00
• 26S proteasome non-ATPase regulatory subunit 7 0.99
• 26S proteasome non-ATPase regulatory subunit 7 0.97
• 26S proteasome non-ATPase regulatory subunit 7 homolog A 0.90
• 26S proteasome regulatory subunit RPN8 0.89
• 26S proteasome non-ATPase regulatory subunit 7 homolog B 0.89
• 26S proteasome regulatory subunit rpn-8 0.88
• 26S proteasome regulatory subunit RPN8 0.87
• 26S proteasome regulatory subunit RPN8 0.86
• 26S proteasome regulatory subunit rpn8 0.81
• 26S proteasome non-ATPase regulatory subunit 7 0.78
• Eukaryotic translation initiation factor 3 subunit F 0.77

Co-cited proteins · studied together in the literature

• 26S proteasome regulatory subunit 6B 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome regulatory subunit 7 4 shared papers
• 26S proteasome regulatory subunit 8 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome regulatory subunit 6A 1 shared papers
• 26S proteasome regulatory subunit 7 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 11 3 shared papers

Literature · 12 cited papers

• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The crystal structure of the human Mov34 MPN domain reveals a metal-free dimer. J. Mol. Biol. · 2007
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. Biochem. Biophys. Res. Commun. · 1995
• Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. Eur. J. Biochem. · 1992