26S proteasome non-ATPase regulatory subunit 11

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Classification

Family (Pfam)

PF01399 PCI, PF18503 RPN6_C_helix, PF18055 RPN6_N

InterPro

26S_Proteasome/COP9_Components, PCI_dom, Rpn6_C_helix, Rpn6_N, TPR-like_helical_dom_sf, WH_DNA-bd_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 79

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 67 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0008541 proteasome regulatory particle, lid subcomplex
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0005198 structural molecule activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043248 proteasome assembly
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress
• GO:0048863 stem cell differentiation
• GO:0006511 ubiquitin-dependent protein catabolic process

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 11 1.00
• 26S proteasome non-ATPase regulatory subunit 11 1.00
• 26S proteasome non-ATPase regulatory subunit 11 1.00
• 26S proteasome non-ATPase regulatory subunit 11 1.00
• 26S proteasome non-ATPase regulatory subunit 11A 0.99
• 26S proteasome non-ATPase regulatory subunit 11B 0.98
• COP9 signalosome complex subunit 4 0.90
• COP9 signalosome complex subunit 4 0.90
• COP9 signalosome complex subunit 4 0.90
• COP9 signalosome complex subunit 4 0.90
• COP9 signalosome complex subunit 4 0.90
• COP9 signalosome complex subunit 4 0.90

Co-cited proteins · studied together in the literature

• Forkhead box protein O4 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 4 shared papers
• 26S proteasome regulatory subunit RPN5 1 shared papers
• 26S proteasome regulatory subunit RPN6 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 3 3 shared papers

Literature · 20 cited papers

• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature · 2012
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. Int. J. Biochem. Cell Biol. · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• … and 8 more in the literature graph