26S proteasome non-ATPase regulatory subunit 1

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF13646 HEAT_2, PF01851 PC_rep, PF18004 RPN2_C, PF21505 RPN2_N

InterPro

26S_Psome_Rpn2, ARM-like, ARM-type_fold, Proteasome/cyclosome_rpt, PSMD1_RPN2_N, RPN2_C

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 86

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5V1Y X-ray 1.42A
• 5V1Z X-ray 2.00A
• … and 74 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0035578 azurophil granule lumen
• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0008540 proteasome regulatory particle, base subcomplex
• GO:0034515 proteasome storage granule
• GO:0008021 synaptic vesicle
• GO:0030234 enzyme regulator activity
• GO:0031625 ubiquitin protein ligase binding
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 1 1.00
• 26S proteasome non-ATPase regulatory subunit 1 1.00
• 26S proteasome non-ATPase regulatory subunit 1 1.00
• 26S proteasome non-ATPase regulatory subunit 1 1.00
• AP-2 complex subunit alpha-2 0.84
• AP-2 complex subunit alpha-2 0.84
• AP-2 complex subunit alpha-2 0.83
• Regulatory-associated protein of mTOR 0.81
• AP-2 complex subunit alpha-2 0.81
• Regulatory-associated protein of mTOR 0.80
• Cell division cycle protein 16 homolog 0.79
• Cell division cycle protein 16 homolog 0.79

Co-cited proteins · studied together in the literature

• Ubiquitin carboxyl-terminal hydrolase isozyme L5 2 shared papers
• Proteasomal ubiquitin receptor ADRM1 2 shared papers
• Ubiquitin carboxyl-terminal hydrolase isozyme L5 1 shared papers
• AN1-type zinc finger protein 1 1 shared papers
• CDC48-associated ubiquitin-like/zinc finger protein 1 1 shared papers
• 26S proteasome regulatory subunit 6B 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• Proteasome subunit alpha type-1 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers

Literature · 20 cited papers

• ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. Mol. Cell · 2018
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• … and 8 more in the literature graph