26S proteasome non-ATPase regulatory subunit 12

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01399 PCI, PF22241 PSMD12-CSN4_N, PF18098 RPN5_C

InterPro

PCI_dom, PSMD12-CSN4-like_N, PSMD12/CSN4, RPN5_C, WH-like_DNA-bd_sf, WH_DNA-bd_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 79

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 67 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0008541 proteasome regulatory particle, lid subcomplex
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Disease associations

• Stankiewicz-Isidor syndrome MONDO:0054591

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 12 1.00
• 26S proteasome non-ATPase regulatory subunit 12 1.00
• COP9 signalosome complex subunit 4 0.82
• COP9 signalosome complex subunit 2 0.79
• COP9 signalosome complex subunit 4 0.79
• 26S proteasome non-ATPase regulatory subunit 11B 0.79
• COP9 signalosome complex subunit 4 0.79
• 26S proteasome non-ATPase regulatory subunit 11A 0.78
• COP9 signalosome complex subunit 4 0.77
• 26S proteasome non-ATPase regulatory subunit 11 0.77
• COP9 signalosome complex subunit 4 0.77
• COP9 signalosome complex subunit 4 0.77

Co-cited proteins · studied together in the literature

• 26S proteasome non-ATPase regulatory subunit 11 4 shared papers
• 26S proteasome regulatory subunit RPN5 1 shared papers
• 26S proteasome regulatory subunit RPN6 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 3 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 3 shared papers
• Ubiquitin C-terminal hydrolase PSMD14 3 shared papers

Literature · 20 cited papers

• De novo disruption of the proteasome regulatory subunit PSMD12 causes a syndromic neurodevelopmental disorder. Am. J. Hum. Genet. · 2017
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PLoS ONE · 2015
• SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
• Uncovering global SUMOylation signaling networks in a site-specific manner. Nat. Struct. Mol. Biol. · 2014
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• … and 8 more in the literature graph