26S proteasome non-ATPase regulatory subunit 3

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01399 PCI, PF08375 Rpn3_C, PF25573 TPR_PSMD3_N

InterPro

CSN3, PCI_dom, PSMD3_C, TPR-like_helical_dom_sf, TPR_PSMD3_N, WH_DNA-bd_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 79

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 67 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0008541 proteasome regulatory particle, lid subcomplex
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0030234 enzyme regulator activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress
• GO:0006511 ubiquitin-dependent protein catabolic process

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 3 1.00
• 26S proteasome non-ATPase regulatory subunit 3 1.00
• Probable 26S proteasome non-ATPase regulatory subunit 3 0.83
• COP9 signalosome complex subunit 1 0.82
• COP9 signalosome complex subunit 1 0.82
• COP9 signalosome complex subunit 1 0.82
• COP9 signalosome complex subunit 1 0.82
• Probable 26S proteasome non-ATPase regulatory subunit 3 0.81
• COP9 signalosome complex subunit 4 0.81
• COP9 signalosome complex subunit 4 0.81
• COP9 signalosome complex subunit 4 0.80
• COP9 signalosome complex subunit 4 0.80

Co-cited proteins · studied together in the literature

• 26S proteasome regulatory subunit RPN3 1 shared papers
• 26S proteasome regulatory subunit RPN10 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 4 4 shared papers
• Ubiquitin-ribosomal protein eL40 fusion protein 1 shared papers
• Ubiquilin-1 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers

Literature · 16 cited papers

• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PLoS ONE · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 4 more in the literature graph