26S proteasome non-ATPase regulatory subunit 13

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01399 PCI, PF22037 PSD13_N

InterPro

PCI_dom, PSD13_N, PSMD13, WH_DNA-bd_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 79

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 67 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0008541 proteasome regulatory particle, lid subcomplex
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0005198 structural molecule activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress
• GO:0006511 ubiquitin-dependent protein catabolic process

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 13 1.00
• 26S proteasome non-ATPase regulatory subunit 13 1.00
• 26S proteasome non-ATPase regulatory subunit 13 0.99
• 26S proteasome non-ATPase regulatory subunit 13 0.99
• 26S proteasome non-ATPase regulatory subunit 13 homolog B 0.91
• 26S proteasome non-ATPase regulatory subunit 13 homolog A 0.90
• COP9 signalosome complex subunit 4 0.86
• COP9 signalosome complex subunit 4 0.86
• COP9 signalosome complex subunit 4 0.86
• COP9 signalosome complex subunit 4 0.86
• COP9 signalosome complex subunit 4 0.86
• COP9 signalosome complex subunit 4 0.86

Co-cited proteins · studied together in the literature

• 26S proteasome regulatory subunit RPN9 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 10 1 shared papers
• Probable 26S proteasome regulatory subunit p28 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 11 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 3 3 shared papers

Literature · 13 cited papers

• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome. FEBS Lett. · 1999
• cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene · 1998
• … and 1 more in the literature graph