26S proteasome regulatory subunit 10B

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Classification

Family (Pfam)

PF00004 AAA, PF17862 AAA_lid_3, PF16450 Prot_ATP_ID_OB_C

InterPro

26S_Proteasome_ATPase, AAA+_ATPase, AAA_lid_3, ATPase_AAA_core, ATPase_AAA_CS, NA-bd_OB-fold, P-loop_NTPase, Prot_ATP_ID_OB_2nd

Functional cluster

ABC Transporter ATPases & DnaJ Chaperones

Experimental structures · PDB · 72

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4G EM 4.02A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 60 more

A predicted model is available from AlphaFold.

Gene Ontology · 25

• GO:0005829 cytosol
• GO:0031597 cytosolic proteasome complex
• GO:0070062 extracellular exosome
• GO:0016234 inclusion body
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0008540 proteasome regulatory particle, base subcomplex
• GO:0008021 synaptic vesicle
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042802 identical protein binding
• GO:0036402 proteasome-activating activity
• GO:0030674 protein-macromolecule adaptor activity
• GO:0071357 cellular response to type I interferon
• GO:0036503 ERAD pathway
• GO:0090261 positive regulation of inclusion body assembly
• GO:1901800 positive regulation of proteasomal protein catabolic process
• GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome regulatory subunit 10B 1.00
• 26S proteasome regulatory subunit 10B 1.00
• 26S proteasome regulatory subunit 10B 1.00
• 26S proteasome regulatory subunit 10B 0.92
• Probable 26S proteasome regulatory subunit 10B 0.92
• 26S proteasome regulatory subunit 8 0.91
• 26S proteasome regulatory subunit 8 0.91
• 26S proteasome regulatory subunit 8 0.91
• 26S proteasome regulatory subunit 8 0.91
• 26S proteasome regulatory subunit 8 0.91
• 26S proteasome regulatory subunit 7 0.91
• Probable 26S proteasome subunit rpt4 0.90

Co-cited proteins · studied together in the literature

• 26S proteasome non-ATPase regulatory subunit 9 1 shared papers
• 26S proteasome regulatory subunit 6A 5 shared papers
• Proteasomal ATPase-associated factor 1 1 shared papers
• 26S proteasome regulatory subunit 4 4 shared papers
• 26S proteasome regulatory subunit 6B 4 shared papers
• 26S proteasome regulatory subunit 7 4 shared papers
• 26S proteasome regulatory subunit 8 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers

Literature · 14 cited papers

• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol. Cell. Biol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. FEBS Lett. · 1996
• … and 2 more in the literature graph