26S proteasome non-ATPase regulatory subunit 8

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF10075 CSN8_PSD8_EIF3K

InterPro

26S_Psome_Rpn12, CSN8_PSD8_EIF3K, PCI_dom

Functional cluster

Zinc-Finger Nucleic-Acid-Binding & Methyltransferases

Experimental structures · PDB · 78

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 66 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0008541 proteasome regulatory particle, lid subcomplex
• GO:0008021 synaptic vesicle
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 8 0.93
• 26S proteasome non-ATPase regulatory subunit 8 0.84
• 26S proteasome non-ATPase regulatory subunit 8 0.81
• 26S proteasome non-ATPase regulatory subunit 8 0.68
• 26S proteasome non-ATPase regulatory subunit 8 homolog A 0.66
• 26S proteasome regulatory subunit rpn12 0.61
• Putative 26S proteasome non-ATPase regulatory subunit 8 homolog B 0.61
• Eukaryotic translation initiation factor 3 subunit K 0.56
• Eukaryotic translation initiation factor 3 subunit K 0.55
• Eukaryotic translation initiation factor 3 subunit K 0.55
• Eukaryotic translation initiation factor 3 subunit K 0.55
• Probable 26S proteasome non-ATPase regulatory subunit 8 0.55

Co-cited proteins · studied together in the literature

• 26S proteasome regulatory subunit RPN12 1 shared papers
• Replication termination factor 2 1 shared papers
• Protein DDI1 homolog 1 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 4 4 shared papers
• 26S proteasome non-ATPase regulatory subunit 6 3 shared papers
• Protein DDI1 homolog 2 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 11 3 shared papers

Literature · 12 cited papers

• Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Mol. Cell · 2018
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and biology of human chromosome 19. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. · 1995
• Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. Eur. J. Biochem. · 1992