26S proteasome non-ATPase regulatory subunit 6

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Classification

Family (Pfam)

PF01399 PCI, PF10602 RPN7, PF21154 RPN7_PSMD6_C

InterPro

PCI_dom, Rpn7/CSN1, Rpn7_N, RPN7_PSMD6_C, TPR-like_helical_dom_sf, WH_DNA-bd_sf

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 78

• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4K EM 4.50A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• 5VFQ EM 4.20A
• … and 66 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0005654 nucleoplasm
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0005838 proteasome regulatory particle
• GO:0034774 secretory granule lumen
• GO:0008021 synaptic vesicle
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome non-ATPase regulatory subunit 6 1.00
• 26S proteasome non-ATPase regulatory subunit 6 0.99
• 26S proteasome non-ATPase regulatory subunit 6 0.96
• 26S proteasome non-ATPase regulatory subunit 6 homolog 0.91
• 26S proteasome regulatory subunit rpn7 0.90
• 26S proteasome non-ATPase regulatory subunit 6 0.89
• 26S proteasome non-ATPase regulatory subunit 6 0.89
• 26S proteasome non-ATPase regulatory subunit 6 0.88
• 26S proteasome regulatory subunit RPN7 0.83
• Eukaryotic translation initiation factor 3 subunit E 0.77
• Eukaryotic translation initiation factor 3 subunit E 0.76
• Eukaryotic translation initiation factor 3 subunit E 0.76

Co-cited proteins · studied together in the literature

• 26S proteasome non-ATPase regulatory subunit 13 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 7 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 12 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 8 3 shared papers
• 26S proteasome regulatory subunit 10B 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 2 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 11 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 3 shared papers
• 26S proteasome non-ATPase regulatory subunit 3 3 shared papers
• Ubiquitin C-terminal hydrolase PSMD14 3 shared papers
• 26S proteasome regulatory subunit 4 3 shared papers
• 26S proteasome regulatory subunit 6A 3 shared papers

Literature · 14 cited papers

• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. Oncogene · 2000
• … and 2 more in the literature graph