26S proteasome regulatory subunit 6B

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Classification

Family (Pfam)

PF00004 AAA, PF17862 AAA_lid_3, PF16450 Prot_ATP_ID_OB_C

InterPro

26S_Proteasome_ATPase, AAA+_ATPase, AAA_lid_3, ATPase_AAA_core, ATPase_AAA_CS, NA-bd_OB-fold, P-loop_NTPase, Prot_ATP_ID_OB_2nd

Functional cluster

ABC Transporter ATPases & DnaJ Chaperones

Experimental structures · PDB · 87

• 2DVW X-ray 2.30A
• 5GJQ EM 4.50A
• 5GJR EM 3.50A
• 5L4G EM 4.02A
• 5LN3 EM 6.80A
• 5M32 EM 3.80A
• 5T0C EM 3.80A
• 5T0G EM 4.40A
• 5T0H EM 6.80A
• 5T0I EM 8.00A
• 5T0J EM 8.00A
• 5VFP EM 4.20A
• … and 75 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005829 cytosol
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0022624 proteasome accessory complex
• GO:0000502 proteasome complex
• GO:0008540 proteasome regulatory particle, base subcomplex
• GO:0008021 synaptic vesicle
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0036402 proteasome-activating activity
• GO:0071357 cellular response to type I interferon
• GO:0010498 proteasomal protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0006508 proteolysis
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:0006979 response to oxidative stress

Drugs targeting this protein · 6

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• 26S proteasome regulatory subunit 6B 1.00
• 26S proteasome regulatory subunit 6B 1.00
• 26S proteasome regulatory subunit 6B 1.00
• 26S proteasome regulatory subunit 6B 1.00
• 26S proteasome regulatory subunit 6B 0.97
• 26S proteasome regulatory subunit 6B homolog 0.92
• 26S proteasome regulatory subunit 6B homolog 0.91
• Probable 26S proteasome regulatory subunit 6B 0.89
• 26S proteasome regulatory subunit 6B homolog 0.88
• 26S proteasome regulatory subunit 6B homolog 0.88
• 26S proteasome regulatory subunit 6B homolog 0.87
• 26S proteasome regulatory subunit 8 homolog 0.85

Co-cited proteins · studied together in the literature

• 26S proteasome regulatory subunit 6A 5 shared papers
• 26S proteasome regulatory subunit 6B 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 10 1 shared papers
• Nuclear receptor subfamily 1 group I member 3 1 shared papers
• 26S proteasome regulatory subunit 6B 1 shared papers
• Nuclear receptor subfamily 1 group I member 3 1 shared papers
• AN1-type zinc finger protein 1 1 shared papers
• 26S proteasome non-ATPase regulatory subunit 1 4 shared papers
• 26S proteasome regulatory subunit 10B 4 shared papers
• Proteasomal ATPase-associated factor 1 1 shared papers
• 26S proteasome regulatory subunit 7 5 shared papers
• CDC48-associated ubiquitin-like/zinc finger protein 1 1 shared papers

Literature · 25 cited papers

• ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. Mol. Cell · 2018
• An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol. · 2016
• Structure of the human 26S proteasome at a resolution of 3.9 Aa. Proc. Natl. Acad. Sci. U.S.A. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• … and 13 more in the literature graph