Small ribosomal subunit protein eS24

UniProt P62847 Organism Homo sapiens Gene RPS24

Also known as: RPS24

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF01282 Ribosomal_S24e
InterPro: eRP_eS24_sf, Ribosomal_eS24, Ribosomal_eS24_CS, Ribosomal_uL23/eL15/eS24_sf
Functional cluster: S-Adenosylmethionine Synthases & related

Experimental structures · PDB · 177

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 165 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Disease associations

Diamond-Blackfan anemia 3 MONDO:0012529

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS13 1 shared papers
Small ribosomal subunit protein uS15 1 shared papers
Small ribosomal subunit protein eS25 1 shared papers
Small ribosomal subunit protein eS8 1 shared papers
Small ribosomal subunit protein uS19 1 shared papers
Small ribosomal subunit protein uS9 1 shared papers
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 1 shared papers
Small ribosomal subunit protein uS11 1 shared papers
Small ribosomal subunit protein eS4, X isoform 1 shared papers
Small ribosomal subunit protein uS7 1 shared papers
Small ribosomal subunit protein uS17 1 shared papers
Small ribosomal subunit protein uS8 1 shared papers

Literature · 20 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder. Hum. Mol. Genet. · 2008
The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
… and 8 more in the literature graph

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