Small ribosomal subunit protein uS11

UniProt P62263 Organism Homo sapiens Gene RPS14

Also known as: RPS14

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF00411 Ribosomal_S11
InterPro: Ribosomal_uS11, Ribosomal_uS11_CS, Ribosomal_uS11_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 176

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 164 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein eS17 1 shared papers
Small ribosomal subunit protein eS17 2 shared papers
Small ribosomal subunit protein uS13 1 shared papers
Small ribosomal subunit protein eS24 1 shared papers
Small ribosomal subunit protein uS15 1 shared papers
Small ribosomal subunit protein eS25 1 shared papers
Small ribosomal subunit protein eS8 1 shared papers
Small ribosomal subunit protein uS19 1 shared papers
Small ribosomal subunit protein uS9 1 shared papers
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 1 shared papers
Small ribosomal subunit protein eS4, X isoform 1 shared papers
Small ribosomal subunit protein uS7 1 shared papers

Literature · 20 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
… and 8 more in the literature graph

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