Small ribosomal subunit protein eS4, X isoform

UniProt P62701 Organism Homo sapiens Gene CCG2, RPS4, RPS4X, SCAR

Also known as: CCG2, RPS4, RPS4X, SCAR

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF16121 40S_S4_C, PF00467 KOW, PF00900 Ribosomal_S4e, PF08071 RS4NT
InterPro: KOW, Rib_uL2_dom2, Ribosomal_eS4, Ribosomal_eS4_C, Ribosomal_eS4_central_region, Ribosomal_eS4_central_sf, Ribosomal_eS4_KOW, Ribosomal_eS4_N, Ribosomal_eS4_N_CS, S4_RNA-bd, S4_RNA-bd_sf
Functional cluster: Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 172

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
6G4W EM 4.50A
6G51 EM 4.10A
… and 160 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein eS4, Y isoform 1 1 shared papers
Small ribosomal subunit protein eS8 2 shared papers
Small ribosomal subunit protein uS13 1 shared papers
Small ribosomal subunit protein eS24 1 shared papers
ELAV-like protein 2 1 shared papers
Small ribosomal subunit protein uS4 2 shared papers
Small ribosomal subunit protein eS1 2 shared papers
Small ribosomal subunit protein uS15 1 shared papers
Small ribosomal subunit protein eS25 1 shared papers
Small ribosomal subunit protein uS19 1 shared papers
Small ribosomal subunit protein uS9 1 shared papers
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 1 shared papers

Literature · 14 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell. Proteomics · 2007
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. · 1996
Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. Somat. Cell Mol. Genet. · 1988
… and 2 more in the literature graph

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