Small ribosomal subunit protein eS25

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF03297 Ribosomal_S25

InterPro

Ribosomal_eS25, WH-like_DNA-bd_sf

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 172

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• … and 160 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0014069 postsynaptic density
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0042274 ribosomal small subunit biogenesis
• GO:0006364 rRNA processing
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS25 1.00
• Small ribosomal subunit protein eS25 1.00
• Small ribosomal subunit protein eS25 1.00
• Small ribosomal subunit protein eS25 1.00
• Small ribosomal subunit protein eS25 0.99
• Small ribosomal subunit protein eS25 0.98
• Small ribosomal subunit protein eS25 0.93
• Small ribosomal subunit protein eS25 0.93
• Small ribosomal subunit protein eS25 0.93
• Small ribosomal subunit protein eS25 0.92
• Small ribosomal subunit protein eS25 0.89
• Small ribosomal subunit protein eS25 0.88

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS9 2 shared papers
• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein eS12 2 shared papers
• Small ribosomal subunit protein uS13 1 shared papers
• Small ribosomal subunit protein eS24 1 shared papers
• Small ribosomal subunit protein eS21 2 shared papers
• Small ribosomal subunit protein eS27 2 shared papers
• Small ribosomal subunit protein uS4 2 shared papers
• Small ribosomal subunit protein eS28 2 shared papers

Literature · 11 cited papers

• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. · 1996
• Cloning and sequencing a cDNA encoding human ribosomal protein S25. Gene · 1991