Large ribosomal subunit protein eL32

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01655 Ribosomal_L32e

InterPro

Ribosomal_eL32, Ribosomal_eL32_CS, Ribosomal_eL32_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 155

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0016020 membrane
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL32 1.00
• Large ribosomal subunit protein eL32 1.00
• Large ribosomal subunit protein eL32 1.00
• Large ribosomal subunit protein eL32 1.00
• Large ribosomal subunit protein eL32 0.99
• Large ribosomal subunit protein eL32 0.95
• Putative large ribosomal subunit protein eL32' 0.89
• Large ribosomal subunit protein eL32 0.84
• Large ribosomal subunit protein uL15 0.81
• Large ribosomal subunit protein uL15 0.81
• Large ribosomal subunit protein uL15 0.81
• Large ribosomal subunit protein uL15 0.81

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers
• Large ribosomal subunit protein uL4 1 shared papers
• Small ribosomal subunit protein eS25 1 shared papers
• Small ribosomal subunit protein uS9 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Large ribosomal subunit protein eL14 1 shared papers
• Large ribosomal subunit protein eL24 1 shared papers
• Large ribosomal subunit protein eL39 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein eL37 1 shared papers
• Small ribosomal subunit protein uS7 1 shared papers

Literature · 13 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc. Natl. Acad. Sci. U.S.A. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• … and 1 more in the literature graph