Large ribosomal subunit protein eL39

Function

RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00832 Ribosomal_L39

InterPro

Ribosomal_eL39, Ribosomal_eL39_CS, Ribosomal_eL39_dom_sf

Functional cluster

Bacterial Ribosomal Proteins

Experimental structures · PDB · 142

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 130 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005615 extracellular space
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019731 antibacterial humoral response
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
• GO:0002181 cytoplasmic translation
• GO:0050830 defense response to Gram-positive bacterium
• GO:0002227 innate immune response in mucosa
• GO:1901740 negative regulation of myoblast fusion
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL39 1.00
• Large ribosomal subunit protein eL39 1.00
• Large ribosomal subunit protein eL39 1.00
• Large ribosomal subunit protein eL39 1.00
• Large ribosomal subunit protein eL39 0.99
• Large ribosomal subunit protein eL39-like 0.97
• Putative ribosomal protein eL39-like 5 0.95
• Large ribosomal subunit protein eL39y 0.94
• Large ribosomal subunit protein eL39 0.94
• Large ribosomal subunit protein eL39 0.94
• Ribosomal protein eL39-like 2 0.94
• Large ribosomal subunit protein eL39z/eL39x 0.93

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein eS27 2 shared papers
• Large ribosomal subunit protein eL36 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein eL22 1 shared papers
• Large ribosomal subunit protein eL39 1 shared papers
• Large ribosomal subunit protein eL14 2 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers
• Large ribosomal subunit protein uL4 1 shared papers
• Small ribosomal subunit protein eS25 1 shared papers

Literature · 8 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. Genomics · 2001
• Primary structures and sequence analysis of human ribosomal proteins L39 and S27. Biochem. Mol. Biol. Int. · 1996
• Molecular cloning of a cDNA encoding human ribosomal protein L39. Biochim. Biophys. Acta · 1996