Large ribosomal subunit protein eL30

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01248 Ribosomal_L7Ae

InterPro

Ribosomal_eL30, Ribosomal_eL30-like, Ribosomal_eL30-like_sf, Ribosomal_eL30_CS, Ribosomal_eL8/eL30/eS12/Gad45

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 146

• 3VI6 X-ray 1.59A
• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 134 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005634 nucleus
• GO:0014069 postsynaptic density
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
• GO:0002181 cytoplasmic translation
• GO:0050829 defense response to Gram-negative bacterium
• GO:0031640 killing of cells of another organism
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL30 1.00
• Large ribosomal subunit protein eL30 1.00
• Large ribosomal subunit protein eL30 1.00
• Large ribosomal subunit protein eL30 1.00
• Large ribosomal subunit protein eL30 1.00
• Large ribosomal subunit protein eL30 0.99
• Large ribosomal subunit protein eL30 0.99
• Large ribosomal subunit protein eL30 0.97
• Large ribosomal subunit protein eL30 0.96
• Large ribosomal subunit protein eL30 0.89
• Large ribosomal subunit protein eL30 0.89
• Large ribosomal subunit protein eL30x 0.88

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein uL4 1 shared papers
• Small ribosomal subunit protein eS25 1 shared papers
• Small ribosomal subunit protein uS9 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Large ribosomal subunit protein eL14 1 shared papers
• Large ribosomal subunit protein eL24 1 shared papers
• Large ribosomal subunit protein eL39 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein eL37 1 shared papers
• Small ribosomal subunit protein uS7 1 shared papers

Literature · 18 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e. Acta Crystallogr. F · 2011
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• … and 6 more in the literature graph