Large ribosomal subunit protein eL24

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01246 Ribosomal_L24e

InterPro

L24e/L24_sf, Ribosomal_eL24, Ribosomal_eL24-rel_N, Ribosomal_eL24_CS, TRASH_dom

Functional cluster

Photosystem II Reaction-Center & Antimicrobial Peptides

Experimental structures · PDB · 90

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6OLE EM 3.10A
• … and 78 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0045202 synapse
• GO:0045296 cadherin binding
• GO:0003729 mRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL24 1.00
• Large ribosomal subunit protein eL24 1.00
• Large ribosomal subunit protein eL24 1.00
• Large ribosomal subunit protein eL24 1.00
• Large ribosomal subunit protein eL24 1.00
• Large ribosomal subunit protein eL24 0.99
• Large ribosomal subunit protein eL24 0.99
• Large ribosomal subunit protein eL24 0.99
• Large ribosomal subunit protein eL24 0.97
• Large ribosomal subunit protein eL24y 0.94
• Large ribosomal subunit protein eL24z 0.94
• Large ribosomal subunit protein eL24 0.94

Co-cited proteins · studied together in the literature

• Protein mono-ADP-ribosyltransferase PARP16 1 shared papers
• Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 1 shared papers
• Small ribosomal subunit protein eS6 1 shared papers
• Large ribosomal subunit protein uL22 2 shared papers
• Large ribosomal subunit protein eL37 2 shared papers
• Large ribosomal subunit protein eL38 1 shared papers
• Large ribosomal subunit protein uL6 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein eS12 2 shared papers
• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers

Literature · 19 cited papers

• Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Cell · 2021
• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• … and 7 more in the literature graph