Large ribosomal subunit protein uL6

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00347 Ribosomal_L6

InterPro

Ribosomal_uL6-like, Ribosomal_uL6-like_a/b-dom_sf, Ribosomal_uL6_a/b-dom, Ribosomal_uL6_CS2

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 154

• 2CQL NMR
• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 142 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0005840 ribosome
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL6 1.00
• Large ribosomal subunit protein uL6 1.00
• Large ribosomal subunit protein uL6 1.00
• Large ribosomal subunit protein uL6 1.00
• Large ribosomal subunit protein uL6 0.99
• Large ribosomal subunit protein uL6 0.99
• Large ribosomal subunit protein uL6 0.98
• Large ribosomal subunit protein uL6 0.93
• Large ribosomal subunit protein uL6 0.93
• Large ribosomal subunit protein uL6 0.90
• Large ribosomal subunit protein uL6 0.90
• Large ribosomal subunit protein uL6 0.89

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL38 1 shared papers
• Large ribosomal subunit protein eL24 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein eL37 1 shared papers
• Small ribosomal subunit protein uS7 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS8 1 shared papers
• Large ribosomal subunit protein uL16 1 shared papers
• Small ribosomal subunit protein eS12 1 shared papers
• Large ribosomal subunit protein uL15 1 shared papers
• Small ribosomal subunit protein eS19 1 shared papers
• Small ribosomal subunit protein eS21 1 shared papers

Literature · 13 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• A map of 75 human ribosomal protein genes. Genome Res. · 1998
• Structural organization and chromosomal localization of the human ribosomal protein L9 gene. Biochim. Biophys. Acta · 1996
• … and 1 more in the literature graph