Large ribosomal subunit protein uL15

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00828 Ribosomal_L27A

InterPro

Rbsml_uL15_N, Ribosomal_uL15, Ribosomal_uL15/eL18, Ribosomal_uL15/eL18_sf, Ribosomal_uL15_CS

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 154

• 4BXF X-ray 2.05A
• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 142 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 0.99
• Large ribosomal subunit protein uL15 0.99
• Large ribosomal subunit protein uL15 0.99
• Large ribosomal subunit protein uL15 0.99
• Large ribosomal subunit protein uL15 0.89
• Large ribosomal subunit protein eL32 0.79
• Large ribosomal subunit protein eL32 0.79
• Large ribosomal subunit protein eL32 0.79
• Large ribosomal subunit protein eL32 0.79

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL15 1 shared papers
• Ribosomal protein uL16 3-hydroxylase 1 shared papers
• Ribosomal oxygenase 2 1 shared papers
• Large ribosomal subunit protein uL2 2 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Ribosomal oxygenase 1 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein uS4 2 shared papers
• Small ribosomal subunit protein uS14 2 shared papers
• Large ribosomal subunit protein uL16 1 shared papers
• Large ribosomal subunit protein eL21 2 shared papers
• Small ribosomal subunit protein eS10 2 shared papers

Literature · 16 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat. Chem. Biol. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 4 more in the literature graph