Large ribosomal subunit protein uL2

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF03947 Ribosomal_L2_C, PF00181 Ribosomal_L2_N

InterPro

NA-bd_OB-fold, Rib_uL2_dom2, Ribosomal_uL2, Ribosomal_uL2_arc_euk, Ribosomal_uL2_C, Ribosomal_uL2_CS, Ribosomal_uL2_dom3, Ribosomal_uL2_RNA-bd_dom, Translation_prot_SH3-like_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 142

• 4CCM X-ray 2.51A
• 4CCN X-ray 2.23A
• 4CCO X-ray 2.30A
• 4UG0 EM
• 4V6X EM 5.00A
• 4Y3O X-ray 2.20A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• … and 130 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0098794 postsynapse
• GO:0014069 postsynaptic density
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 1.00
• Large ribosomal subunit protein uL2 0.98
• Large ribosomal subunit protein uL2 0.98
• Large ribosomal subunit protein uL2 0.98
• Large ribosomal subunit protein uL2 0.98

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL2 1 shared papers
• Large ribosomal subunit protein uL2 1 shared papers
• Ribosomal protein uL16 3-hydroxylase 1 shared papers
• Large ribosomal subunit protein uL15 2 shared papers
• Ribosomal oxygenase 2 1 shared papers
• Ribosomal oxygenase 1 1 shared papers
• Large ribosomal subunit protein uL22 3 shared papers
• Large ribosomal subunit protein uL16 1 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• Large ribosomal subunit protein eL14 2 shared papers
• Large ribosomal subunit protein eL34 3 shared papers
• Large ribosomal subunit protein uL16 2 shared papers

Literature · 17 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat. Chem. Biol. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat. Biotechnol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• … and 5 more in the literature graph