Large ribosomal subunit protein uL16

UniProt P0ADY7 Organism Escherichia coli (strain K12) Gene JW3275, b3313, rplP

Also known as: JW3275, b3313, rplP

Function

Binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center. It contacts the A and P site tRNAs. One of the last ribosomal proteins to be assembled in the 50S subunit. The simultaneous presence of uL16 and bL36 probably triggers ObgE's GTPase activity and eventual dissociation from the mature 50S ribosomal subunit. It has an essential role in subunit assembly.

Classification

Family (Pfam): PF00252 Ribosomal_L16
InterPro: Ribosomal_uL16, Ribosomal_uL16_bact, Ribosomal_uL16_CS, Ribosomal_uL16_dom, Ribosomal_uL16_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 534

2J28 EM 8.00A
2RDO EM 9.10A
3BBX EM 10.00A
3J5L EM 6.60A
3J7Z EM 3.90A
3J8G EM 5.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
3JBU EM 3.64A
3JBV EM 3.32A
3JCD EM 3.70A
… and 522 more

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Dual-action ribosomal maturation protein DarP 2 shared papers
Large ribosomal subunit protein bL36A 4 shared papers
Small ribosomal subunit protein uS13 2 shared papers
Ribosomal protein uL16 3-hydroxylase 1 shared papers
Ribosomal oxygenase 2 1 shared papers
Large ribosomal subunit protein uL15 1 shared papers
Large ribosomal subunit protein bL33 3 shared papers
Small ribosomal subunit protein uS19 2 shared papers
Large ribosomal subunit protein uL2 1 shared papers
Ribosomal oxygenase 1 1 shared papers
Ribosomal large subunit pseudouridine synthase D 1 shared papers
Large ribosomal subunit protein uL2 4 shared papers

Literature · 20 cited papers

YjgA plays dual roles in enhancing PTC maturation. Nucleic Acids Res. · 2024
Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol. Cell · 2021
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat. Chem. Biol. · 2012
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
… and 8 more in the literature graph

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