Large ribosomal subunit protein uL2

UniProt P60422 Organism Escherichia coli (strain K12) Gene JW3279, b3317, rplB

Also known as: JW3279, b3317, rplB

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial (Probable).

Classification

Family (Pfam): PF03947 Ribosomal_L2_C, PF00181 Ribosomal_L2_N
InterPro: NA-bd_OB-fold, Rib_uL2_dom2, Ribosomal_uL2, Ribosomal_uL2_bact_org, Ribosomal_uL2_C, Ribosomal_uL2_CS, Ribosomal_uL2_dom3, Ribosomal_uL2_RNA-bd_dom, Translation_prot_SH3-like_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 579

2J28 EM 8.00A
2RDO EM 9.10A
3BBX EM 10.00A
3J5L EM 6.60A
3J7Z EM 3.90A
3J8G EM 5.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
3JBU EM 3.64A
3JBV EM 3.32A
3JCD EM 3.70A
… and 567 more

A predicted model is available from AlphaFold.

Gene Ontology · 11

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL2 1 shared papers
Large ribosomal subunit protein uL2 1 shared papers
Large ribosomal subunit protein uL3 5 shared papers
Large ribosomal subunit protein bL25 4 shared papers
Large ribosomal subunit protein bL9 4 shared papers
Large ribosomal subunit protein uL1 4 shared papers
Cell division activator CedA 1 shared papers
Large ribosomal subunit protein uL6 3 shared papers
Large ribosomal subunit protein uL14 4 shared papers
Large ribosomal subunit protein uL11 3 shared papers
Large ribosomal subunit protein uL16 4 shared papers
Putative RNA-binding protein YbcJ 1 shared papers

Literature · 23 cited papers

Identification of functional interactome of a key cell division regulatory protein CedA of E.coli. Int. J. Biol. Macromol. · 2018
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
… and 11 more in the literature graph

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