lmmol · Proteins

Large ribosomal subunit protein uL1

UniProt P0A7L0 Organism Escherichia coli (strain K12) Gene JW3947, b3984, rplA

Also known as: JW3947, b3984, rplA

Function

One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms. This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation. Contacts the P and E site tRNAs.

Classification

Family (Pfam)
PF00687 Ribosomal_L1
InterPro
Ribosom_uL1_bact, Ribosomal_uL1, Ribosomal_uL1-like, Ribosomal_uL1/biogenesis, Ribosomal_uL1_3-a/b-sand, Ribosomal_uL1_CS
Functional cluster
Glycolytic Enzymes & Elongation Factor Ts

Experimental structures · PDB · 151

A predicted model is available from AlphaFold.

Gene Ontology · 11

Drugs targeting this protein · 62

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 18 cited papers

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