Large ribosomal subunit protein uL10
Also known as: JW3948, b3985, rplJ
Function
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Classification
- Family (Pfam)
- PF00466 Ribosomal_L10, PF27436 RL10_C
- InterPro
- Ribosomal_uL10, Ribosomal_uL10-like_sf, Ribosomal_uL10_bact, Ribosomal_uL10_bact_orga, Ribosomal_uL10_CS_bac
- Functional cluster
- Ribosomal Proteins & Trigger Factor
Experimental structures · PDB · 188
- 3J7Z EM 3.90A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JCJ EM 3.70A
- 4UY8 EM 3.80A
- 4V6N EM 12.10A
- 4V6O EM 14.70A
- 4V6P EM 13.50A
- 4V6Q EM 11.50A
- 4V6R EM 11.50A
- 4V6S EM 13.10A
- … and 176 more
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0022625 cytosolic large ribosomal subunit
- GO:0015934 large ribosomal subunit
- GO:0070180 large ribosomal subunit rRNA binding
- GO:0043022 ribosome binding
- GO:0003735 structural constituent of ribosome
- GO:0002181 cytoplasmic translation
- GO:0017148 negative regulation of translation
- GO:0006412 translation
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
- Large ribosomal subunit protein uL10 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein bL12 5 shared papers
- Large ribosomal subunit protein uL11 3 shared papers
- Large ribosomal subunit protein uL10 1 shared papers
- Large ribosomal subunit protein bL12 1 shared papers
- Large ribosomal subunit protein uL1 1 shared papers
- Large ribosomal subunit protein uL10 1 shared papers
- DNA-directed RNA polymerase subunit beta 1 shared papers
- Large ribosomal subunit protein uL10 1 shared papers
- Large ribosomal subunit protein bL12 1 shared papers
- Large ribosomal subunit protein bL12 1 shared papers
- Large ribosomal subunit protein uL30 1 shared papers
- Large ribosomal subunit protein bL33 1 shared papers
Literature · 18 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G. Nucleic Acids Res. · 2012
- Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria. Proc. Natl. Acad. Sci. U.S.A. · 2005
- Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
- The complete genome sequence of Escherichia coli K-12. Science · 1997
- … and 6 more in the literature graph
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