DNA-directed RNA polymerase subunit beta

UniProt P0A8V2 Organism Escherichia coli (strain K12) Gene JW3950, b3987, groN, nitB, rif, ron, rpoB, stl, stv, tabD EC 2.7.7.6

Also known as: JW3950, b3987, groN, nitB, rif, ron, rpoB, stl, stv, tabD

Function

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Classification

Family (Pfam): PF04563 RNA_pol_Rpb2_1, PF04561 RNA_pol_Rpb2_2, PF04565 RNA_pol_Rpb2_3, PF10385 RNA_pol_Rpb2_45, PF00562 RNA_pol_Rpb2_6, PF04560 RNA_pol_Rpb2_7
InterPro: DNA-dir_RNA_pol_bsu_ext_1_sf, DNA-dir_RNA_pol_bsu_external_1, DNA-dir_RNA_pol_su2, DNA-dir_RNAP_su2_dom, DNA-dir_RNAP_su2_hyb_sf, RNA_pol_bsu_bac, RNA_pol_bsu_CS, RNA_pol_bsu_protrusion, RNA_pol_Rpb2_2, RNA_pol_Rpb2_2_sf, RNA_pol_Rpb2_3, RNA_pol_Rpb2_7, RNA_pol_RPB2_OB-fold
Functional cluster: DNA-Directed RNA Polymerase Subunits

Experimental structures · PDB · 362

3IYD EM
3LTI X-ray 1.60A
3LU0 EM
3T72 X-ray 4.33A
3TBI X-ray 3.00A
4JK1 X-ray 3.90A
4JK2 X-ray 4.20A
4KMU X-ray 3.85A
4KN4 X-ray 3.96A
4KN7 X-ray 3.69A
4MEX X-ray 3.90A
4MEY X-ray 3.95A
… and 350 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

Drugs targeting this protein · 7

RIFAXIMIN inhibitor
RIFAPENTINE inhibitor
RIFAMYCIN SODIUM inhibitor
RIFALAZIL inhibitor
RIFAMPIN inhibitor
RIFABUTIN inhibitor
RIFAQUIZINONE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

DNA-directed RNA polymerase subunit beta' 7 shared papers
Antitermination protein Q 2 shared papers
Late transcription coactivator 1 shared papers
DNA-directed RNA polymerase subunit alpha 6 shared papers
RNA polymerase sigma factor RpoD 3 shared papers
DNA-directed RNA polymerase subunit omega 3 shared papers
Transcription termination/antitermination protein NusA 2 shared papers
DNA-binding transcriptional dual regulator CRP 2 shared papers
Large ribosomal subunit protein uL10 1 shared papers
Cell division activator CedA 1 shared papers
Peptidyl-lysine N-acetyltransferase PatZ 1 shared papers
Large ribosomal subunit protein uL11 1 shared papers

Literature · 19 cited papers

Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol. Cell · 2020
NusA directly interacts with antitermination factor Q from phage lambda. Sci. Rep. · 2020
Identification of functional interactome of a key cell division regulatory protein CedA of E.coli. Int. J. Biol. Macromol. · 2018
Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife · 2014
Crystal structure of the bacteriophage T4 late-transcription coactivator gp33 with the beta-subunit flap domain of Escherichia coli RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. · 2011
Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter. Mol. Microbiol. · 2011
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc. Natl. Acad. Sci. U.S.A. · 2009
The bacteriophage lambda Q antiterminator protein contacts the beta-flap domain of RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. · 2008
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Escherichia coli proteome analysis using the gene-protein database. Electrophoresis · 1997
The complete genome sequence of Escherichia coli K-12. Science · 1997
… and 7 more in the literature graph

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