DNA-directed RNA polymerase subunit omega
Also known as: JW3624, b3649, rpoZ
Function
Promotes RNA polymerase (RNAP) assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Classification
- Family (Pfam)
- PF01192 RNA_pol_Rpb6
- InterPro
- DNA-dir_RNA_pol_omega, Pol_omega/Rpo6/RPB6, RPB6/omega-like_sf
- Functional cluster
- F/V-Type ATP Synthases & RecA/SecA ATPases
Experimental structures · PDB · 348
- 3IYD EM
- 3LU0 EM
- 4JK1 X-ray 3.90A
- 4JK2 X-ray 4.20A
- 4KMU X-ray 3.85A
- 4KN4 X-ray 3.96A
- 4KN7 X-ray 3.69A
- 4MEX X-ray 3.90A
- 4MEY X-ray 3.95A
- 4XSX X-ray 3.71A
- 4XSY X-ray 4.01A
- 4XSZ X-ray 3.68A
- … and 336 more
A predicted model is available from AlphaFold.
Gene Ontology · 19
- GO:0005829 cytosol
- GO:0000345 cytosolic DNA-directed RNA polymerase complex
- GO:0030880 RNA polymerase complex
- GO:0001000 bacterial-type RNA polymerase core enzyme binding
- GO:0003677 DNA binding
- GO:0003899 DNA-directed RNA polymerase activity
- GO:0044780 bacterial-type flagellum assembly
- GO:0071973 bacterial-type flagellum-dependent cell motility
- GO:0048870 cell motility
- GO:0036460 cellular response to cell envelope stress
- GO:0006352 DNA-templated transcription initiation
- GO:0006879 intracellular iron ion homeostasis
- GO:0042128 nitrate assimilation
- GO:0065003 protein-containing complex assembly
- GO:0032784 regulation of DNA-templated transcription elongation
- GO:2000142 regulation of DNA-templated transcription initiation
- GO:0009408 response to heat
- GO:0090605 submerged biofilm formation
- GO:0031564 transcription antitermination
Drugs targeting this protein · 7
- RIFAXIMIN inhibitor
- RIFAPENTINE inhibitor
- RIFAMYCIN SODIUM inhibitor
- RIFALAZIL inhibitor
- RIFAMPIN inhibitor
- RIFABUTIN inhibitor
- RIFAQUIZINONE inhibitor
Related proteins · sequence + function similarity
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
- DNA-directed RNA polymerase subunit omega 1.00
Co-cited proteins · studied together in the literature
- tRNA (guanosine(18)-2'-O)-methyltransferase 1 shared papers
- DNA-directed RNA polymerase subunit beta' 3 shared papers
- Bifunctional (p)ppGpp synthase/hydrolase SpoT 1 shared papers
- DNA-directed RNA polymerase subunit beta 3 shared papers
- DNA-directed RNA polymerase subunit alpha 3 shared papers
- RNA polymerase sigma factor RpoD 2 shared papers
- DNA-binding transcriptional dual regulator CRP 1 shared papers
- Transcription termination/antitermination protein NusG 1 shared papers
- Nus factor SuhB 1 shared papers
- Transcription termination/antitermination protein NusA 1 shared papers
- Small ribosomal subunit protein uS10 1 shared papers
- Small ribosomal subunit protein uS4 1 shared papers
Literature · 9 cited papers
- Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol. Cell · 2020
- Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife · 2014
- Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc. Natl. Acad. Sci. U.S.A. · 2009
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Small genes/gene-products in Escherichia coli K-12. FEMS Microbiol. Lett. · 1998
- The complete genome sequence of Escherichia coli K-12. Science · 1997
- DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics · 1993
- The cloning and sequence of the gene encoding the omega subunit of Escherichia coli RNA polymerase. Gene · 1986
- Characterization of the spoT gene of Escherichia coli. J. Biol. Chem. · 1989
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