DNA-directed RNA polymerase subunit beta'

UniProt P0A8T7 Organism Escherichia coli (strain K12) Gene JW3951, b3988, rpoC, tabB EC 2.7.7.6

Also known as: JW3951, b3988, rpoC, tabB

Function

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Classification

Family (Pfam): PF04997 RNA_pol_Rpb1_1, PF00623 RNA_pol_Rpb1_2, PF04983 RNA_pol_Rpb1_3, PF05000 RNA_pol_Rpb1_4, PF04998 RNA_pol_Rpb1_5
InterPro: DNA-dir_RpoC_beta_prime, DNA-dir_RpoC_beta_prime_bact, RNA_pol_asu, RNA_pol_N, RNA_pol_Rpb1_1, RNA_pol_Rpb1_3, RNA_pol_Rpb1_3_sf, RNA_pol_Rpb1_4, RNA_pol_Rpb1_5, RNA_pol_Rpb1_clamp_domain, Rpb1_funnel_sf
Functional cluster: DNA-Directed RNA Polymerase Subunits

Experimental structures · PDB · 358

2AUK X-ray 2.30A
2LMC NMR
3IYD EM
3LU0 EM
4IQZ X-ray 2.10A
4JK1 X-ray 3.90A
4JK2 X-ray 4.20A
4KMU X-ray 3.85A
4KN4 X-ray 3.96A
4KN7 X-ray 3.69A
4MEX X-ray 3.90A
4MEY X-ray 3.95A
… and 346 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

Drugs targeting this protein · 7

RIFAXIMIN inhibitor
RIFAPENTINE inhibitor
RIFAMYCIN SODIUM inhibitor
RIFALAZIL inhibitor
RIFAMPIN inhibitor
RIFABUTIN inhibitor
RIFAQUIZINONE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

DNA-directed RNA polymerase subunit beta 7 shared papers
DNA-directed RNA polymerase subunit alpha 6 shared papers
RNA polymerase sigma factor RpoD 3 shared papers
DNA-directed RNA polymerase subunit omega 3 shared papers
DNA-binding transcriptional dual regulator CRP 2 shared papers
Peptidyl-lysine N-acetyltransferase PatZ 1 shared papers
Transcription termination/antitermination protein NusG 1 shared papers
Nus factor SuhB 1 shared papers
Transcription termination/antitermination protein NusA 1 shared papers
Small ribosomal subunit protein uS10 1 shared papers
Small ribosomal subunit protein uS4 1 shared papers
Transcription antitermination protein NusB 1 shared papers

Literature · 14 cited papers

Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol. Cell · 2020
Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife · 2014
Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter. Mol. Microbiol. · 2011
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc. Natl. Acad. Sci. U.S.A. · 2009
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Escherichia coli proteome analysis using the gene-protein database. Electrophoresis · 1997
The complete genome sequence of Escherichia coli K-12. Science · 1997
Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Nucleic Acids Res. · 1993
The primary structure of E. coli RNA polymerase, Nucleotide sequence of the rpoC gene and amino acid sequence of the beta'-subunit. Nucleic Acids Res. · 1982
Nucleotide sequence at the end of the gene for the RNA polymerase beta' subunit (rpoC). Nucleic Acids Res. · 1981
The primary structure of Escherichia coli RNA polymerase. Nucleotide sequence of the rpoB gene and amino-acid sequence of the beta-subunit. Eur. J. Biochem. · 1981
… and 2 more in the literature graph

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