Small ribosomal subunit protein uS4

UniProt P0A7V8 Organism Escherichia coli (strain K12) Gene JW3258, b3296, ramA, rpsD

Also known as: JW3258, b3296, ramA, rpsD

Function

One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.

Classification

Family (Pfam): PF00163 Ribosomal_S4, PF01479 S4
InterPro: Ribosomal_uS4, Ribosomal_uS4_bact, Ribosomal_uS4_CS, Ribosomal_uS4_N, S4_RNA-bd, S4_RNA-bd_sf
Functional cluster: Photosystem Reaction-Center Proteins

Experimental structures · PDB · 529

1EG0 EM 11.50A
2YKR EM 9.80A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
3JBU EM 3.64A
3JBV EM 3.32A
3JCD EM 3.70A
3JCE EM 3.20A
3JCJ EM 3.70A
3JCN EM 4.60A
4A2I EM 16.50A
… and 517 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS12 3 shared papers
Small ribosomal subunit protein uS3 4 shared papers
DNA-directed RNA polymerase subunit alpha 3 shared papers
Small ribosomal subunit protein uS7 3 shared papers
Small ribosomal subunit protein uS5 2 shared papers
Small ribosomal subunit protein uS2 3 shared papers
Small ribosomal subunit protein uS11 2 shared papers
Small ribosomal subunit protein uS13 2 shared papers
Large ribosomal subunit protein bL17 1 shared papers
Small ribosomal subunit protein bS1 1 shared papers
Small ribosomal subunit protein bS18 2 shared papers
Small ribosomal subunit protein uS10 2 shared papers

Literature · 25 cited papers

Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol. Cell · 2020
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
mRNA helicase activity of the ribosome. Cell · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
Ribosomal protein S4 is a transcription factor with properties remarkably similar to NusA, a protein involved in both non-ribosomal and ribosomal RNA antitermination. EMBO J. · 2001
… and 13 more in the literature graph

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