Small ribosomal subunit protein uS2
Also known as: JW0164, b0169, rpsB
Function
Required for ribosomal protein bS1 (rpsA) to bind to the 30S subunit.
Classification
- Family (Pfam)
- PF00318 Ribosomal_S2
- InterPro
- Ribosomal_uS2, Ribosomal_uS2_bac/mit/plastid, Ribosomal_uS2_CS, Ribosomal_uS2_flav_dom_sf
- Functional cluster
- Ribosome-Recycling & Clp Protease Factors
Experimental structures · PDB · 509
- 2YKR EM 9.80A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- 3JBV EM 3.32A
- 3JCD EM 3.70A
- 3JCE EM 3.20A
- 3JCJ EM 3.70A
- 3JCN EM 4.60A
- 4A2I EM 16.50A
- 4ADV EM 13.50A
- … and 497 more
A predicted model is available from AlphaFold.
Gene Ontology · 6
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
- Small ribosomal subunit protein uS2 1.00
Co-cited proteins · studied together in the literature
- Small ribosomal subunit protein bS1 3 shared papers
- Elongation factor Ts 1 shared papers
- Small ribosomal subunit protein uS3 4 shared papers
- Glyoxalase ElbB 1 shared papers
- Thioredoxin reductase 1 shared papers
- Alkyl hydroperoxide reductase C 1 shared papers
- Small ribosomal subunit protein uS4 3 shared papers
- Large ribosomal subunit protein bL9 1 shared papers
- Ribosome rescue factor SmrB 1 shared papers
- Small ribosomal subunit protein bS21 2 shared papers
- Isocitrate dehydrogenase [NADP] 1 shared papers
- Large ribosomal subunit protein bL9 2 shared papers
Literature · 22 cited papers
- Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature · 2022
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Identification of lysine succinylation as a new post-translational modification. Nat. Chem. Biol. · 2011
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
- Effects of ribosomal proteins S1, S2 and the DeaD/CsdA DEAD-box helicase on translation of leaderless and canonical mRNAs in Escherichia coli. Mol. Microbiol. · 2002
- … and 10 more in the literature graph
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