Small ribosomal subunit protein bS18

Function

Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.

Classification

Family (Pfam)

PF01084 Ribosomal_S18

InterPro

Ribosomal_bS18, Ribosomal_bS18_CS, Ribosomal_bS18_sf

Functional cluster

Ribosomal Proteins (S5/S18, L17/L22)

Experimental structures · PDB · 515

• 2YKR EM 9.80A
• 3IY8 EM 14.10A
• 3J9Y EM 3.90A
• 3J9Z EM 3.60A
• 3JA1 EM 3.60A
• 3JBU EM 3.64A
• 3JBV EM 3.32A
• 3JCD EM 3.70A
• 3JCE EM 3.20A
• 3JCJ EM 3.70A
• 3JCN EM 4.60A
• 4A2I EM 16.50A
• … and 503 more

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0048027 mRNA 5'-UTR binding
• GO:0070181 small ribosomal subunit rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation

Drugs targeting this protein · 62

• TELITHROMYCIN inhibitor
• DEMECLOCYCLINE HYDROCHLORIDE inhibitor
• ERYTHROMYCIN LACTOBIONATE inhibitor
• ERYTHROMYCIN STEARATE inhibitor
• CLINDAMYCIN HYDROCHLORIDE inhibitor
• CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
• QUINUPRISTIN inhibitor
• ERYTHROMYCIN ETHYLSUCCINATE inhibitor
• DOXYCYCLINE inhibitor
• CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
• MINOCYCLINE HYDROCHLORIDE inhibitor
• DALFOPRISTIN inhibitor
• TETRACYCLINE PHOSPHATE COMPLEX inhibitor
• DIRITHROMYCIN inhibitor
• TEDIZOLID inhibitor
• LINEZOLID inhibitor
• CHLORAMPHENICOL inhibitor
• TETRACYCLINE inhibitor
• KANAMYCIN SULFATE inhibitor
• LINCOMYCIN inhibitor
• OXYTETRACYCLINE inhibitor
• OXYTETRACYCLINE HYDROCHLORIDE inhibitor
• DELPAZOLID inhibitor
• CLARITHROMYCIN inhibitor
• BEKANAMYCIN inhibitor
• ERAVACYCLINE inhibitor
• OMADACYCLINE TOSYLATE inhibitor
• TYLVALOSIN TARTRATE inhibitor
• TEDIZOLID PHOSPHATE inhibitor
• GAMITHROMYCIN inhibitor
• CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
• METHACYCLINE HYDROCHLORIDE inhibitor
• PAROMOMYCIN SULFATE inhibitor
• SISOMICIN inhibitor
• ERYTHROMYCIN ESTOLATE inhibitor
• ERAVACYCLINE DIHYDROCHLORIDE inhibitor
• JOSAMYCIN inhibitor
• PLAZOMICIN SULFATE inhibitor
• MECLOCYCLINE SULFOSALICYLATE inhibitor
• TILDIPIROSIN inhibitor
• QUINUPRISTIN/DALFOPRISTIN inhibitor
• CLINDAMYCIN PHOSPHATE inhibitor
• STREPTOMYCIN SULFATE inhibitor
• DIHYDROSTREPTOMYCIN SULFATE inhibitor
• CONTEZOLID inhibitor
• ERYTHROMYCIN GLUCEPTATE inhibitor
• LEFAMULIN ACETATE inhibitor
• CADAZOLID inhibitor
• TIGECYCLINE inhibitor
• OXYTETRACYCLINE CALCIUM inhibitor
• SPECTINOMYCIN HYDROCHLORIDE inhibitor
• DOXYCYCLINE HYCLATE inhibitor
• NETILMICIN SULFATE inhibitor
• PIRLIMYCIN HYDROCHLORIDE inhibitor
• CETHROMYCIN inhibitor
• CONTEZOLID ACEFOSAMIL inhibitor
• AMIKACIN SULFATE inhibitor
• NAFITHROMYCIN inhibitor
• TETRACYCLINE HYDROCHLORIDE inhibitor
• RADEZOLID inhibitor
• AZITHROMYCIN inhibitor
• ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00
• Small ribosomal subunit protein bS18 1.00

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein bS6 2 shared papers
• Large ribosomal subunit protein bL9 1 shared papers
• Replication restart protein PriB 1 shared papers
• Small ribosomal subunit protein uS9 2 shared papers
• Small ribosomal subunit protein uS17 2 shared papers
• Small ribosomal subunit protein uS3 2 shared papers
• Small ribosomal subunit protein uS14 1 shared papers
• Small ribosomal subunit protein uS12 2 shared papers
• Small ribosomal subunit protein uS2 2 shared papers
• Small ribosomal subunit protein uS4 2 shared papers
• Small ribosomal subunit protein bS16 1 shared papers
• Small ribosomal subunit protein uS8 1 shared papers

Literature · 15 cited papers

• Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
• Translational termination without a stop codon. Science · 2016
• Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
• Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
• Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
• Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
• All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
• Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
• The complete genome sequence of Escherichia coli K-12. Science · 1997
• Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. · 1995
• … and 3 more in the literature graph