Small ribosomal subunit protein uS14

Function

Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.

Classification

Family (Pfam)

PF00253 Ribosomal_S14

InterPro

Ribosomal_uS14, Ribosomal_uS14_bact_plastid, Ribosomal_uS14_CS

Functional cluster

Bacterial Ribosomal Proteins

Experimental structures · PDB · 510

• 2YKR EM 9.80A
• 3J9Y EM 3.90A
• 3J9Z EM 3.60A
• 3JA1 EM 3.60A
• 3JBU EM 3.64A
• 3JBV EM 3.32A
• 3JCD EM 3.70A
• 3JCE EM 3.20A
• 3JCJ EM 3.70A
• 3JCN EM 4.60A
• 4A2I EM 16.50A
• 4ADV EM 13.50A
• … and 498 more

A predicted model is available from AlphaFold.

Gene Ontology · 9

• GO:0005737 cytoplasm
• GO:0022627 cytosolic small ribosomal subunit
• GO:0015935 small ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0002181 cytoplasmic translation
• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Drugs targeting this protein · 62

• TELITHROMYCIN inhibitor
• DEMECLOCYCLINE HYDROCHLORIDE inhibitor
• ERYTHROMYCIN LACTOBIONATE inhibitor
• ERYTHROMYCIN STEARATE inhibitor
• CLINDAMYCIN HYDROCHLORIDE inhibitor
• CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
• QUINUPRISTIN inhibitor
• ERYTHROMYCIN ETHYLSUCCINATE inhibitor
• DOXYCYCLINE inhibitor
• CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
• MINOCYCLINE HYDROCHLORIDE inhibitor
• DALFOPRISTIN inhibitor
• TETRACYCLINE PHOSPHATE COMPLEX inhibitor
• DIRITHROMYCIN inhibitor
• TEDIZOLID inhibitor
• LINEZOLID inhibitor
• CHLORAMPHENICOL inhibitor
• TETRACYCLINE inhibitor
• KANAMYCIN SULFATE inhibitor
• LINCOMYCIN inhibitor
• OXYTETRACYCLINE inhibitor
• OXYTETRACYCLINE HYDROCHLORIDE inhibitor
• DELPAZOLID inhibitor
• CLARITHROMYCIN inhibitor
• BEKANAMYCIN inhibitor
• ERAVACYCLINE inhibitor
• OMADACYCLINE TOSYLATE inhibitor
• TYLVALOSIN TARTRATE inhibitor
• TEDIZOLID PHOSPHATE inhibitor
• GAMITHROMYCIN inhibitor
• CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
• METHACYCLINE HYDROCHLORIDE inhibitor
• PAROMOMYCIN SULFATE inhibitor
• SISOMICIN inhibitor
• ERYTHROMYCIN ESTOLATE inhibitor
• ERAVACYCLINE DIHYDROCHLORIDE inhibitor
• JOSAMYCIN inhibitor
• PLAZOMICIN SULFATE inhibitor
• MECLOCYCLINE SULFOSALICYLATE inhibitor
• TILDIPIROSIN inhibitor
• QUINUPRISTIN/DALFOPRISTIN inhibitor
• CLINDAMYCIN PHOSPHATE inhibitor
• STREPTOMYCIN SULFATE inhibitor
• DIHYDROSTREPTOMYCIN SULFATE inhibitor
• CONTEZOLID inhibitor
• ERYTHROMYCIN GLUCEPTATE inhibitor
• LEFAMULIN ACETATE inhibitor
• CADAZOLID inhibitor
• TIGECYCLINE inhibitor
• OXYTETRACYCLINE CALCIUM inhibitor
• SPECTINOMYCIN HYDROCHLORIDE inhibitor
• DOXYCYCLINE HYCLATE inhibitor
• NETILMICIN SULFATE inhibitor
• PIRLIMYCIN HYDROCHLORIDE inhibitor
• CETHROMYCIN inhibitor
• CONTEZOLID ACEFOSAMIL inhibitor
• AMIKACIN SULFATE inhibitor
• NAFITHROMYCIN inhibitor
• TETRACYCLINE HYDROCHLORIDE inhibitor
• RADEZOLID inhibitor
• AZITHROMYCIN inhibitor
• ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS8 2 shared papers
• Small ribosomal subunit protein uS5 2 shared papers
• Large ribosomal subunit protein uL30 1 shared papers
• Large ribosomal subunit protein uL15 1 shared papers
• Large ribosomal subunit protein uL6 1 shared papers
• Large ribosomal subunit protein uL24 1 shared papers
• Large ribosomal subunit protein uL18 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Small ribosomal subunit protein bS16 1 shared papers
• Small ribosomal subunit protein bS18 1 shared papers
• Small ribosomal subunit protein bS20 1 shared papers
• Small ribosomal subunit protein bS6 1 shared papers

Literature · 12 cited papers

• Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
• Translational termination without a stop codon. Science · 2016
• Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
• Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
• Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
• Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
• All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
• Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
• The complete genome sequence of Escherichia coli K-12. Science · 1997
• The spc ribosomal protein operon of Escherichia coli: sequence and cotranscription of the ribosomal protein genes and a protein export gene. Nucleic Acids Res. · 1983