Large ribosomal subunit protein uL24

UniProt P60624 Organism Escherichia coli (strain K12) Gene JW3271, b3309, rplX

Also known as: JW3271, b3309, rplX

Function

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. It is not thought to be involved in the functions of the mature 50S subunit in vitro.

Classification

Family (Pfam): PF00467 KOW, PF17136 ribosomal_L24
InterPro: KOW, Rib_uL2_dom2, Ribosomal_uL24, Ribosomal_uL24_C, Ribosomal_uL24_CS, Ribosomal_uL24_KOW, Translation_prot_SH3-like_sf
Functional cluster: Ribosomal Proteins (S16/S17/L24/L30)

Experimental structures · PDB · 566

1ML5 EM 14.00A
2J28 EM 8.00A
2RDO EM 9.10A
2VRH EM 19.00A
3BBX EM 10.00A
3J45 EM 9.50A
3J46 EM 10.10A
3J5L EM 6.60A
3J7Z EM 3.90A
3J8G EM 5.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
… and 554 more

A predicted model is available from AlphaFold.

Gene Ontology · 8

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL3 4 shared papers
Small ribosomal subunit protein uS8 2 shared papers
Large ribosomal subunit protein uL5 4 shared papers
Large ribosomal subunit protein uL15 4 shared papers
Large ribosomal subunit protein uL23 4 shared papers
Large ribosomal subunit protein uL30 3 shared papers
Protein-export membrane protein SecG 1 shared papers
Large ribosomal subunit protein uL29 3 shared papers
Protein translocase subunit SecY 2 shared papers
Large ribosomal subunit protein uL13 3 shared papers
Small ribosomal subunit protein uS14 1 shared papers
Large ribosomal subunit protein uL6 3 shared papers

Literature · 19 cited papers

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature · 2005
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
… and 7 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.